INT196920

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.65
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (E2f1) nucleus (E2f1) cell cycle (E2f1)
DNA binding (E2f1) transcription factor binding (E2f1) cytoplasm (E2f1)
Anatomy Link Frequency
pituitary 1
E2f1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 44 93.04 High High
cytokine 22 78.60 Quite High
antagonist 2 57.44 Quite High
sodium channel 2 54.64 Quite High
opioid receptor 2 33.28 Quite Low
interstitial cystitis 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 81 99.84 Very High Very High Very High
Immune System Diseases 2 97.92 Very High Very High Very High
Targeted Disruption 33 96.20 Very High Very High Very High
Cancer 61 95.88 Very High Very High Very High
Overactive Bladder 36 95.16 Very High Very High Very High
Disease 6 93.48 High High
INFLAMMATION 52 93.04 High High
Retinoblastoma 6 68.84 Quite High
Dermatological Disease 2 64.32 Quite High
Repression 6 64.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Does the afore-reported HMGA2-dependent molecular events result in enhanced E2F1-dependent gene transcription in pituitary adenomas?
Transcription (transcription) of E2F1 in pituitary associated with pituitary cancer
1) Confidence 0.68 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.52 Pain Relevance 0
In fact it blocks the pRB-dependent inhibition of both E2F1 target gene transcription and cell proliferation.
Transcription (transcription) of E2F1
2) Confidence 0.51 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.35 Pain Relevance 0
The transcriptional activity of E2F1 is repressed in non-proliferating cells by its interaction with pRB that masks the activation domain of E2F1, and prevents it to contact the general transcription machinery [30].
Transcription (activity) of E2F1
3) Confidence 0.51 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.59 Pain Relevance 0
The transcription factor E2F1 is in a central position.
Transcription (transcription) of E2F1
4) Confidence 0.38 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.49 Pain Relevance 0.03
Network 5 (Figure 4A) presents FOS, IL-6, and the transcription factor E2F1 in a central position and overlays with the aryl hydrocarbon receptor canonic pathway (GSTA5, GSTP1, GSTM1, Rar [all trans retinoic acid receptor], FOS, IL-6, E2F1, and retinoic acid).
Transcription (transcription) of E2F1
5) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.70 Pain Relevance 0.19

General Comments

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