INT196923

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Hmga2) enzyme binding (Hmga2) DNA binding (Hmga2)
mitosis (Hmga2) signal transduction (Hmga2) nucleus (Hmga2)
Hmga2 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 10 99.64 Very High Very High Very High
Targeted Disruption 55 98.24 Very High Very High Very High
Cancer 15 97.68 Very High Very High Very High
Pituitary Cancer 135 93.52 High High
Prolactinoma 15 90.32 High High
Benign Tumor 5 83.40 Quite High
Repression 10 79.84 Quite High
Malignant Neoplastic Disease 5 69.32 Quite High
Adenoma 20 66.28 Quite High
Syndrome 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HMGA2 binds to pRB and inhibits its function
HMGA2 Binding (binds) of
1) Confidence 0.47 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.74 Pain Relevance 0
These results suggest that the binding between HMGA2 and pRB may be generally involved in HMGA2-mediated cell transformation.


HMGA2 Binding (binding) of
2) Confidence 0.47 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.23 Pain Relevance 0
Based on the striking mirror similarities between the phenotypes of pRB [22,35] and HMGA2 [36,37] animal models, our group has recently investigated a potential functional interaction between HMGA2 and the Retinoblastoma protein [38].
HMGA2 Binding (interaction) of associated with retinoblastoma
3) Confidence 0.47 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.43 Pain Relevance 0
Interestingly, we found that the interaction between HMGA2 and pRB is crucial for the transforming activity of HMGA2 protein.
HMGA2 Binding (interaction) of
4) Confidence 0.37 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.30 Pain Relevance 0
Thus, even though HMGA2 is still able to bind pRB in the absence of E2F1, there are no other proteins belonging to the E2F family, whose DNA binding activity is enhanced following the HMGA2/pRB interaction.
HMGA2 Binding (interaction) of
5) Confidence 0.35 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.79 Pain Relevance 0

General Comments

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