INT196925

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.16
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) cell cycle (Rb1)
DNA binding (Rb1) cell division (Rb1) transcription factor binding (Rb1)
Anatomy Link Frequency
soma 2
Rb1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 80 99.04 Very High Very High Very High
ischemia 32 97.88 Very High Very High Very High
agonist 10 54.96 Quite High
Somatosensory cortex 11 36.88 Quite Low
cva 5 21.88 Low Low
anesthesia 6 5.56 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Coagulation Disorder 13 99.84 Very High Very High Very High
Pressure And Volume Under Development 101 99.36 Very High Very High Very High
Cv Unclassified Under Development 28 97.88 Very High Very High Very High
Skin Cancer 10 97.80 Very High Very High Very High
Brain Hemorrhage 48 97.28 Very High Very High Very High
Thrombosis 8 96.96 Very High Very High Very High
Cancer 75 95.68 Very High Very High Very High
Necrosis 22 87.44 High High
Rhinitis 1 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recently, a new mechanism of pRB-mediated E2F1 repression has been suggested in addition to this one.
Positive_regulation (mediated) of Gene_expression (repression) of pRB associated with repression
1) Confidence 0.45 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.48 Pain Relevance 0
Furthermore, RB photoactivation and induction of clotting by a focused laser even within 15 ?
Positive_regulation (induction) of Gene_expression (photoactivation) of RB associated with coagulation disorder
2) Confidence 0.43 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1854912 Disease Relevance 0.33 Pain Relevance 0.18
As observed with CD40 fluorescence labeling, the mean area of the RB-induced lesion increased from 2.07 mm3±0.24 (n?
Positive_regulation (increased) of Gene_expression (lesion) of RB-induced
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.15 Pain Relevance 0.03
Temporal imaging of perivascular astrocytes immediately after a single RB-induced photothrombosis revealed rapid swelling with the average size of the cell soma increasing over 6-fold within 3 hours, from 63±15 µm2 at rest to 382±61 µm2 (mean ± SD, n?
Positive_regulation (single) of Gene_expression (photothrombosis) of RB-induced in soma associated with pressure and volume under development and imagery
4) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 1.07 Pain Relevance 0.12
USC-HN1 cells demonstrate strong, uniform nuclear p53 and Rb expression, as well as positive expression of keratin, E-cadherin, EGFr, and CD44 in situ consistent with HNSCC as well as the original tumor biopsy [4,7,13,19].
Positive_regulation (nuclear) of Gene_expression (expression) of Rb associated with cancer
5) Confidence 0.05 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.12 Pain Relevance 0

General Comments

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