INT196929

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.29
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (E2f1) nucleus (E2f1) cell cycle (E2f1)
DNA binding (E2f1) transcription factor binding (E2f1) cytoplasm (E2f1)
Anatomy Link Frequency
pituitary 3
bladder 1
epithelial cell 1
E2f1 (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 20 98.58 Very High Very High Very High
Inflammation 23 90.80 High High
cytokine 12 66.56 Quite High
Paracetamol 2 49.48 Quite Low
cva 1 23.72 Low Low
interstitial cystitis 3 13.40 Low Low
headache 7 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 3 100.00 Very High Very High Very High
Pituitary Cancer 189 99.66 Very High Very High Very High
Bladder Cancer 9 98.64 Very High Very High Very High
Targeted Disruption 102 97.08 Very High Very High Very High
Retinoblastoma 17 94.60 High High
Apoptosis 84 93.84 High High
INFLAMMATION 28 90.80 High High
Reprotox - General 1 2 72.44 Quite High
Death 5 69.36 Quite High
Cancer 66 68.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acetylation of both histones and E2F1 protein increase about two-fold the E2F1 transcriptional activity.
Positive_regulation (increase) of E2F1 protein
1) Confidence 0.66 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.12 Pain Relevance 0
However, what appears to be really novel, is the mechanism that leads to E2F1 activation by HMGA2: the E2F1 protein is not displaced from the pRB complex, but an increased acetylation that is dependent on the removal of HDAC1 from pRB takes place.
Neg (not) Positive_regulation (displaced) of E2F1 protein
2) Confidence 0.48 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.46 Pain Relevance 0
Does the afore-reported HMGA2-dependent molecular events result in enhanced E2F1-dependent gene transcription in pituitary adenomas?
Positive_regulation (enhanced) of E2F1 in pituitary associated with pituitary cancer
3) Confidence 0.48 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.51 Pain Relevance 0
Our data demonstrate that E2F1 activation is a crucial step required for the onset of pituitary adenomas in HMGA2 transgenic mice.
Positive_regulation (activation) of E2F1 in pituitary associated with targeted disruption and pituitary cancer
4) Confidence 0.44 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.74 Pain Relevance 0
Since HMGA2 amplification and overexpression has been detected also in human pituitary adenomas, we retain that E2F1 activation plays a critical role also in the human pituitary pathology.
Positive_regulation (activation) of E2F1 in pituitary associated with pituitary cancer
5) Confidence 0.44 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.67 Pain Relevance 0
The presence of E2F1 hyperacetylation in the absence of HMGA2 overexpression would suggest the involvement of other proteins acting with the same or similar mechanism of HMGA2 protein, or alternatively other mechanisms that eventually lead to an increase in E2F1 acetylation and subsequent activation.



Positive_regulation (increase) of E2F1
6) Confidence 0.44 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.21 Pain Relevance 0
The acetylation of both histones and E2F1 protein increase about two-fold the E2F1 transcriptional activity.
Positive_regulation (increase) of E2F1
7) Confidence 0.44 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.12 Pain Relevance 0
Interestingly, an E2F1-dependent increase in transcription was found in U1 bladder cancer cells emerging from quiescence upon serum stimulation [42].
Positive_regulation (increase) of E2F1 in bladder associated with bladder cancer
8) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.51 Pain Relevance 0.11
Davis et al. [39] reported that the COX-2 inhibitor NS-398 was more cytotoxic in a prostate epithelial cell line in which E2F1 had been activated than in the original prostate epithelial cell lines, speculating that the reason for the greater cytotoxicity was a disruption in the retinoblastoma/E2F complexes.
Positive_regulation (activated) of E2F1 in epithelial cell associated with cox-2 inhibitor and retinoblastoma
9) Confidence 0.13 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.67 Pain Relevance 0.05
Although NCoA6 was initially cloned as coactivator protein for NRs, its detailed characterization by a number of laboratories has uncovered its potential to enhance the activity of a wide variety of other transcription factors including c-Fos, c-Jun, CREB, NF-kB, ATF-2, heat shock factors, E2F-1, SRF, and Rb, p53 and Sox9 [Goo et al., 2004; Hong et al., 2004a; Hong et al., 2004b; Ko et al., 2000; Kong et al., 2003; Lee et al., 1999; Lee et al., 2000; Mahajan et al., 2007; Mahajan et al., 2002; Mahajan and Samuels, 2000; Mahajan and Samuels, 2005].
Positive_regulation (enhance) of E2F-1 associated with shock
10) Confidence 0.03 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.27 Pain Relevance 0.03

General Comments

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