INT196934

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.41
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac1) nucleus (Hdac1) enzyme binding (Hdac1)
DNA binding (Hdac1) protein complex (Hdac1) transcription factor binding (Hdac1)
Anatomy Link Frequency
oocyte 2
lung 1
Hdac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 55 92.60 High High
Inflammatory response 24 68.32 Quite High
cINOD 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Obstructive Pulmonary Disease 108 95.58 Very High Very High Very High
INFLAMMATION 82 92.60 High High
Pituitary Cancer 27 90.92 High High
Disease 33 88.16 High High
Targeted Disruption 12 75.36 Quite High
Nicotine Addiction 10 41.04 Quite Low
Cancer 7 35.08 Quite Low
Stress 15 30.56 Quite Low
Adenoma 4 29.36 Quite Low
Repression 4 6.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significantly decreased HDAC1 mRNA levels in both oocytes and two-cell embryos from IVM strongly implied that IVM procedure downregulated the transcription of HDAC1 gene in oocytes before and after fertilization.
Negative_regulation (decreased) of HDAC1 mRNA in oocytes
1) Confidence 0.39 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
The defects of HDAC1 mRNA in MII oocytes suggested that the down-regulation of HDAC1 gene resulted from IVM occurred at the early stage of oocyte maturation.
Negative_regulation (regulation) of HDAC1 gene in oocyte
2) Confidence 0.39 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
However, what appears to be really novel, is the mechanism that leads to E2F1 activation by HMGA2: the E2F1 protein is not displaced from the pRB complex, but an increased acetylation that is dependent on the removal of HDAC1 from pRB takes place.
Negative_regulation (removal) of HDAC1
3) Confidence 0.27 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.45 Pain Relevance 0
In addition, as there is a reduction in expression of other HDACs in COPD, including HDAC-3, 5, and 8, it must also be considered that the alteration in the expression and/or activity of other HDACs may also play a role in the impairment of GC function.86 Cigarette smoke exposure results in a reduction of HDAC-1, 2, and 3 in the macrophage cell line, Mono Mac 6 cells, associated with elevated tyrosine nitration and aldehyde adduct formation.88 However, the roles of these HDACs in the lung and inflammatory cells involved in COPD are poorly understood, and studies are needed to clarify their roles in GR function and in disease.


Negative_regulation (reduction) of HDAC-1 in lung associated with inflammation, chronic obstructive pulmonary disease and disease
4) Confidence 0.05 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.96 Pain Relevance 0.11

General Comments

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