INT196937

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.47
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Hmga2) enzyme binding (Hmga2) DNA binding (Hmga2)
mitosis (Hmga2) signal transduction (Hmga2) nucleus (Hmga2)
Anatomy Link Frequency
pituitary 2
hook 1
Hmga2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 90.80 High High
Inflammation 34 89.84 High High
Inflammatory response 2 69.56 Quite High
headache 2 62.24 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 22 99.56 Very High Very High Very High
Pituitary Cancer 54 99.44 Very High Very High Very High
Weight Gain 2 96.92 Very High Very High Very High
Obesity 11 95.68 Very High Very High Very High
Disorder Of Lipid Metabolism 1 94.68 High High
Adenoma 8 91.60 High High
INFLAMMATION 35 89.84 High High
Apoptosis 2 67.92 Quite High
Hypopituitarism 2 62.92 Quite High
Headache 2 62.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, transgenic mice expressing high levels of the HMGA2 gene develop pituitary adenomas secreting prolactin and growth hormone [6], (Figure 1).
Positive_regulation (levels) of HMGA2 in pituitary associated with targeted disruption and pituitary cancer
1) Confidence 0.68 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.85 Pain Relevance 0.06
Recently, our group suggested a critical role for high-mobility group A2 (HMGA2) gene in pituitary oncogenesis.
Positive_regulation (role) of HMGA2 in pituitary
2) Confidence 0.46 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.94 Pain Relevance 0.06
They also induce adipogenesis in fibroblasts in vitro through the induction of genes such as high-mobility group AT-hook 2 (HMGA2) and leptin [8, 14–18].
Positive_regulation (induction) of HMGA2 in hook
3) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 0.67 Pain Relevance 0.16

General Comments

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