INT196939

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.18
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 1.67
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (Stub1) protein binding, bridging (Stub1) enzyme binding (Stub1)
protein maturation (Stub1) ligase activity (Stub1) cytoplasm (Stub1)
Anatomy Link Frequency
neurons 1
Stub1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 240 98.56 Very High Very High Very High
tetrodotoxin 2 98.42 Very High Very High Very High
trigeminal ganglion 66 5.00 Very Low Very Low Very Low
opioid receptor 9 5.00 Very Low Very Low Very Low
Morphine 9 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 267 99.68 Very High Very High Very High
Targeted Disruption 117 96.84 Very High Very High Very High
Pituitary Cancer 81 82.08 Quite High
Sprains And Strains 135 50.00 Quite Low
Repression 55 50.00 Quite Low
Adenoma 12 38.32 Quite Low
Cancer 9 37.52 Quite Low
Ganglion Cysts 70 5.00 Very Low Very Low Very Low
Infection 33 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The primer pairs used for locus-ChIP assays of the NeuroD4, Msc, Tcfap2b and Gata3 loci appear in additional file 5.
Gene_expression (assays) of ChIP
1) Confidence 0.18 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0 Pain Relevance 0
At 4DIV, cultured neurons were treated overnight with tetrodotoxin (TTX, 1µM; Calbiochem, La Jolla, CA), then on DIV5 protein-DNA complexes were processed for ChIP. 4µL purified anti-CaRF antibody (#4510)[15] was added to each lysate (WT and KO) and incubated overnight with rotation at 4°C.
Gene_expression (processed) of ChIP in neurons associated with targeted disruption and tetrodotoxin
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0.35 Pain Relevance 0.10
For quantitation of chromatin immunoprecipitation of RNA polymerase II on the Carf gene, the primers listed in Table S1 were used to amplify a 173bp region flanking the ChIP peaks in Carf exon 1.
Gene_expression (peaks) of ChIP
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0.07 Pain Relevance 0
As shown in Figure 7A and B, ChIP PCR products were detected with HDAC2, NRSF and Sp3 antibody, but were not detected when PI, no antibody or IRF-4 antibody was tested.
Gene_expression (products) of ChIP
4) Confidence 0.08 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.28
ChIP and re-ChIP assay revealed that Sp3 and NRSF were presented together on 188 bp MOR DNA segment for synergic downregulation of MOR expression
Gene_expression (assay) of ChIP associated with mu opioid receptor
5) Confidence 0.08 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.21
ChIP was performed by incubating the cell lysate overnight at 4°C with 4 ?
Gene_expression (performed) of ChIP
6) Confidence 0.08 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0
Thus, as a consequence of the E2F1 acetylation, HMGA2 can indirectly also cause the displacement of E2F1 from pRB as it was observed by ChIP and re-ChIP experiments on the cyclin E1 promoter [38].


Gene_expression (experiments) of ChIP
7) Confidence 0.08 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.39 Pain Relevance 0
Thus, as a consequence of the E2F1 acetylation, HMGA2 can indirectly also cause the displacement of E2F1 from pRB as it was observed by ChIP and re-ChIP experiments on the cyclin E1 promoter [38].


Gene_expression (experiments) of ChIP
8) Confidence 0.07 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.39 Pain Relevance 0
This was convincingly demonstrated by ChIP experiments using antibodies against acetylated histone H3 and E2F1 [38].
Gene_expression (experiments) of ChIP
9) Confidence 0.07 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.07 Pain Relevance 0
Determination of ChIP bound/input ratio
Gene_expression (Determination) of ChIP
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0 Pain Relevance 0
By 4 h post-TCIE our ChIP analyses showed that H3K4me2 enrichment of the ICP4 promoter region returned to latent enrichment profile again demonstrating that increased euchromatic histone mark enrichments on the ICP4 promoter region of HSV-1 are transient and occur rapidly following the application of a reactivation stimulus.
Spec (analyses) Gene_expression (analyses) of ChIP associated with cold sores
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.24 Pain Relevance 0
Subsequent ChIP analyses of the HSV-1 genome of the McKrae virus in the rabbit TG revealed that the H3 K4me2 enrichment of the ICP4 promoter significantly increased ?
Spec (analyses) Gene_expression (analyses) of ChIP associated with cold sores
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox