INT196944

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Rb1, Hdac1) DNA binding (Rb1, Hdac1) nucleus (Rb1, Hdac1)
transcription factor binding (Rb1, Hdac1) protein complex (Hdac1) cytoplasm (Hdac1)
Rb1 (Mus musculus)
Hdac1 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 95.56 Very High Very High Very High
Pituitary Cancer 27 91.36 High High
Retinoblastoma 2 88.32 High High
Repression 2 66.24 Quite High
Targeted Disruption 11 32.72 Quite Low
Adenoma 4 5.00 Very Low Very Low Very Low
Prolactinoma 3 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low
Hypopituitarism 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This interaction was then repeated and confirmed in vitro with recombinant proteins, finding that one of the pRB domains involved in the interaction is the A/B pocket [30], the same domain that is also involved in the interaction with E2F1, HDAC1 and viral oncoproteins such as those produced by the E1A adenovirus [39,40].
pRB Binding (interaction) of HDAC1
1) Confidence 0.24 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.40 Pain Relevance 0

General Comments

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