INT196951

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.98
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Hmga2, E2f1) nucleus (Hmga2, E2f1) cell cycle (Hmga2, E2f1)
transcription factor binding (Hmga2, E2f1) mitochondrion (E2f1) nuclear chromosome (Hmga2)
Hmga2 (Mus musculus)
E2f1 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 54 98.52 Very High Very High Very High
Prolactinoma 6 93.56 High High
Targeted Disruption 22 80.80 Quite High
Cancer 6 40.52 Quite Low
Adenoma 8 34.80 Quite Low
Retinoblastoma 4 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low
Hypopituitarism 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, what appears to be really novel, is the mechanism that leads to E2F1 activation by HMGA2: the E2F1 protein is not displaced from the pRB complex, but an increased acetylation that is dependent on the removal of HDAC1 from pRB takes place.
HMGA2 Positive_regulation (activation) of E2F1
1) Confidence 0.50 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.47 Pain Relevance 0
This mechanism entails the activation of the E2F1 protein by the HMGA2-mediated displacement of HDAC1 from pRB protein.



HMGA2 Positive_regulation (activation) of E2F1 protein
2) Confidence 0.50 Published 2006 Journal Cell Div Section Abstract Doc Link PMC1563461 Disease Relevance 0.51 Pain Relevance 0

General Comments

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