INT196953

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Hmga2, Rb1) DNA binding (Hmga2, Rb1) nucleus (Hmga2, Rb1)
cell cycle (Hmga2, Rb1) cell division (Hmga2, Rb1) transcription factor binding (Hmga2, Rb1)
Hmga2 (Mus musculus)
Rb1 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 84.88 Quite High
Pituitary Cancer 27 80.68 Quite High
Retinoblastoma 2 77.64 Quite High
Repression 2 55.56 Quite High
Targeted Disruption 11 48.00 Quite Low
Adenoma 4 5.00 Very Low Very Low Very Low
Prolactinoma 3 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low
Hypopituitarism 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was very interesting because it suggested that HMGA2, similarly to the viral oncoproteins, could inhibit pRB function by displacing E2F1 and HDAC1 from pRB.
HMGA2 Negative_regulation (inhibit) of pRB
1) Confidence 0.59 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.35 Pain Relevance 0

General Comments

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