INT197

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Context Info
Confidence 0.63
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 12.35
Pain Relevance 8.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hrh2) signal transducer activity (Hrh2)
Anatomy Link Frequency
arterioles 2
sensory neurons 1
blood 1
Hrh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 96 100.00 Very High Very High Very High
agonist 8 100.00 Very High Very High Very High
antinociception 4 99.96 Very High Very High Very High
peptic ulcer disease 11 99.92 Very High Very High Very High
cINOD 9 99.76 Very High Very High Very High
Calcium channel 1 99.60 Very High Very High Very High
noradrenaline 2 99.32 Very High Very High Very High
Pain 20 99.20 Very High Very High Very High
lidocaine 10 98.88 Very High Very High Very High
antidepressant 1 98.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 30 99.96 Very High Very High Very High
Disease 49 99.92 Very High Very High Very High
Ulcers 47 99.72 Very High Very High Very High
Pain 17 99.20 Very High Very High Very High
INFLAMMATION 1 99.04 Very High Very High Very High
Anaemia 12 98.92 Very High Very High Very High
Injury 28 98.72 Very High Very High Very High
Gastroesophageal Reflux Disease 140 98.48 Very High Very High Very High
Kidney Stones 3 98.04 Very High Very High Very High
Recurrence 24 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quality of healing in peptic ulcer disease--are H2 receptor antagonists all we need?
Gene_expression (antagonists) of H2 receptor associated with antagonist, peptic ulcer disease and disease
1) Confidence 0.63 Published 1993 Journal Gastroenterol. Jpn. Section Title Doc Link 8103021 Disease Relevance 0.98 Pain Relevance 0.27
The absence of ranitidine effects on the disposition of lidocaine, a high-extraction, high-clearance drug, suggests that H2-receptor blockade may not decrease hepatic blood flow, and that cimetidine impairs drug elimination only by inhibition of hepatic microsomal enzymes.
Gene_expression (blockade) of H2-receptor in blood associated with lidocaine
2) Confidence 0.61 Published 1985 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 3987178 Disease Relevance 0 Pain Relevance 0.60
In conclusion, lansoprazole is more effective than H2-receptor antagonists in relieving ulcer pain and has a similar safety profile in the healing of gastric and duodenal ulcers.
Gene_expression (antagonists) of H2-receptor associated with pain, antagonist, duodenal ulcer and ulcers
3) Confidence 0.61 Published 1993 Journal Clin Ther Section Abstract Doc Link 7911399 Disease Relevance 0.96 Pain Relevance 0.36
BACKGROUND: Lafutidine, (+/-)-2-(furfurylsulfinyl)-N-[4-[4-(piperidinomethyl)-2-pyridyl]oxy-(Z)-2 butenyl]acetamide, is a newly synthesized histamine H2 receptor antagonist and possesses a cytoprotective efficacy, which comprises mucin biosynthesis and stimulation of gastric blood flow mediated through capsaicin-sensitive sensory neurons and endogenous calcitonin gene-related peptide (CGRP).
Gene_expression (synthesized) of histamine H2 receptor in sensory neurons associated with qutenza, antagonist and calcitonin gene-related peptide
4) Confidence 0.59 Published 2003 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 12542603 Disease Relevance 0 Pain Relevance 0.19
Cimetidine, a representative of the new generation of H2-receptor blockers which are potent inhibitors of gastric secretion, significantly enhances healing of duodenal ulcers.
Gene_expression (generation) of H2-receptor associated with duodenal ulcer
5) Confidence 0.54 Published 1977 Journal Schweiz Med Wochenschr Section Abstract Doc Link 17157 Disease Relevance 1.05 Pain Relevance 0.09
Cimetidine, ranitidine and famotidine are competitive antagonists, while the long-acting H2-receptor antagonists, e.g. loxtidine and lamitidine, are insurmountable H2-receptor blockers.
Gene_expression (blockers) of H2-receptor associated with antagonist
6) Confidence 0.51 Published 1987 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 2908767 Disease Relevance 0.38 Pain Relevance 0.31
Cimetidine, ranitidine and famotidine are competitive antagonists, while the long-acting H2-receptor antagonists, e.g. loxtidine and lamitidine, are insurmountable H2-receptor blockers.
Gene_expression (blockers) of H2-receptor associated with antagonist
7) Confidence 0.51 Published 1987 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 2908767 Disease Relevance 0.38 Pain Relevance 0.31
What are the differences between the H2-receptor antagonists?
Gene_expression (antagonists) of H2-receptor associated with antagonist
8) Confidence 0.51 Published 1987 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 2908767 Disease Relevance 0.18 Pain Relevance 0.25
This response was blocked by pretreatment with H1 and H2 receptor antagonists, but only slightly reduced after systemic capsaicin pretreatment of guinea-pigs.
Gene_expression (antagonists) of H2 receptor associated with qutenza and antagonist
9) Confidence 0.51 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6083460 Disease Relevance 0.09 Pain Relevance 0.67
H2-receptor but not H1-receptor antagonists, administered by intravenous infusion, produce a dose-dependent constriction of superior mesenteric arterioles of the anaesthetized rat under resting conditions.
Gene_expression (produce) of H2-receptor in arterioles associated with antagonist
10) Confidence 0.50 Published 1989 Journal Farmaco Section Abstract Doc Link 2570587 Disease Relevance 0.07 Pain Relevance 0.20
Both H1 and H2 receptor antagonists produce antinociception.
Gene_expression (produce) of H2 receptor associated with antinociception and antagonist
11) Confidence 0.49 Published 2008 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19260335 Disease Relevance 0.82 Pain Relevance 1.20
The secretion evoked by topically applied histamine was resistant to pretreatment with H1 and H2 receptor antagonists i.p.
Gene_expression (antagonists) of H2 receptor associated with antagonist
12) Confidence 0.43 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2566487 Disease Relevance 0 Pain Relevance 0.18
The proton pump inhibitors lansoprazole and omeprazole produce faster rates of healing and greater symptomatic relief in patients with acid-related disorders than histamine2-receptor antagonists, are well tolerated, and are associated with few adverse events.
Gene_expression (produce) of histamine2-receptor associated with antagonist
13) Confidence 0.40 Published 1997 Journal Pharmacotherapy Section Abstract Doc Link 9324183 Disease Relevance 0.75 Pain Relevance 0.21
A prospective, open, multicenter clinical trial was set up to evaluate the potential interaction of ITF 282 with H2-receptor antagonists in patients affected with iron deficiency.
Gene_expression (antagonists) of H2-receptor associated with anaemia and antagonist
14) Confidence 0.37 Published 1993 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 8100220 Disease Relevance 0.41 Pain Relevance 0.09
ITF 282 resulted, also when administered together with H2-receptor antagonists, in the expected therapeutic efficacy, with the expected clinical tolerability and biological safety, without signs of possible interaction, negative or positive.
Gene_expression (antagonists) of H2-receptor associated with antagonist
15) Confidence 0.37 Published 1993 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 8100220 Disease Relevance 0.68 Pain Relevance 0.18
H2-receptor antagonists, with or without the addition of mucosaprotectiva or prokinetica, produce healing only in 50% of the patients.
Gene_expression (produce) of H2-receptor associated with antagonist
16) Confidence 0.31 Published 1989 Journal Digestion Section Abstract Doc Link 2575061 Disease Relevance 0.54 Pain Relevance 0.28
Lafutidine (Laf), a histamine H2 receptor antagonist, has a mucosal protective effect in addition to its antisecretory properties via indirect stimulation or sensitization of CSAN [11–15].
Gene_expression (antagonist) of H2 receptor associated with antagonist
17) Confidence 0.30 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.68 Pain Relevance 0.27
The synthesis and action of H2-receptor antagonists changed the understanding of gastric acid secretion as well as changing medical therapy for peptic ulcer disease.
Gene_expression (synthesis) of H2-receptor associated with peptic ulcer disease, antagonist and disease
18) Confidence 0.30 Published 1993 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 8387826 Disease Relevance 0.19 Pain Relevance 0.15
H2A: Histamine2 receptor antagonist
Gene_expression (antagonist) of Histamine2 receptor associated with antagonist
19) Confidence 0.06 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117603 Disease Relevance 0.61 Pain Relevance 0.17
Drugs often used in the treatment of NSAID-associated mucosal damage include H2-receptor blockers, which inhibit gastric acid secretion, and agents such as synthetic prostaglandins and sucralfate, which improve mucosal defense.
Gene_expression (blockers) of H2-receptor associated with cinod
20) Confidence 0.04 Published 1990 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 2181675 Disease Relevance 0.67 Pain Relevance 0.82

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