INT1970

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Context Info
Confidence 0.75
First Reported 1977
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.46
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gusb) lysosome (Gusb)
Anatomy Link Frequency
neutrophils 6
macrophages 1
skin 1
Gusb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 20 99.76 Very High Very High Very High
cocaine 8 99.66 Very High Very High Very High
cINOD 12 99.28 Very High Very High Very High
bradykinin 4 98.64 Very High Very High Very High
Pain 2 95.16 Very High Very High Very High
Analgesic 4 95.00 High High
local anesthetic 6 94.00 High High
Pain score 1 92.32 High High
Arthritis 3 90.28 High High
lidocaine 3 84.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 28 99.76 Very High Very High Very High
Pressure And Volume Under Development 6 97.68 Very High Very High Very High
Arthritis 2 97.20 Very High Very High Very High
Pain 2 95.16 Very High Very High Very High
Cyanosis 1 93.92 High High
Granuloma 1 91.56 High High
Experimental Arthritis 1 90.28 High High
Syndrome 1 88.52 High High
Erythema 1 87.56 High High
Crystal Associated Disease 2 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the extracts suppressed the release of beta-glucuronidase, a lysosomal enzyme in rat neutrophils.
Localization (release) of beta-glucuronidase in neutrophils
1) Confidence 0.75 Published 1998 Journal Arch. Pharm. Res. Section Abstract Doc Link 9875511 Disease Relevance 0.26 Pain Relevance 0.17
In vitro study in rats showed that DGNTT significantly inhibits the activity of beta-glucuronidase (P < 0.05) and lysozyme release (P < 0.01) from neutrophils.
Localization (release) of beta-glucuronidase in neutrophils
2) Confidence 0.75 Published 1995 Journal Am. J. Chin. Med. Section Abstract Doc Link 8571922 Disease Relevance 0.49 Pain Relevance 0.34
It inhibits zymosan-induced beta-glucuronidase release from cultured macrophages and also the activity of this enzyme.
Localization (release) of beta-glucuronidase in macrophages
3) Confidence 0.58 Published 1978 Journal Agents Actions Section Abstract Doc Link 311146 Disease Relevance 0.75 Pain Relevance 0.30
Both SAID and NSAID reduced the arylsulfatase activity released into the exudate (free activity) dose-relatedly but not the free activity of beta-glucuronidase at 3 h after carrageenin.
Localization (released) of beta-glucuronidase associated with cinod
4) Confidence 0.54 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6583058 Disease Relevance 0.45 Pain Relevance 0.62
AP (10(-5)-10(-3)M) inhibited the sodium urate crystal-induced beta-glucuronidase release from guinea pig neutrophils at more than 10(-4) M.
Localization (release) of beta-glucuronidase in neutrophils
5) Confidence 0.29 Published 1991 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1783328 Disease Relevance 0.49 Pain Relevance 0.35
These studies indicated that guinea-pig neutrophils are capable of a selective release of lysosomal enzymes (beta-glucuronidase) during ingestion of serum-treated zymosan particles and that certain anti-inflammatory drugs and prostaglansins may function as modulators of the phagocytic release of lysosomal enzymes from neutrophils.
Localization (release) of beta-glucuronidase in neutrophils associated with inflammation and cinod
6) Confidence 0.07 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 850132 Disease Relevance 0.17 Pain Relevance 0.13
PGF2alpha accelerated at high and inhibited at low concentrations the selective secretion of beta-glucuronidase from cytochalasin B-treated neutrophils.
Localization (secretion) of beta-glucuronidase in neutrophils
7) Confidence 0.07 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 850132 Disease Relevance 0.07 Pain Relevance 0.12
Guinea-pig neutrophils released lysosome granule-associated beta-glucuronidase, but not cytoplasmic lactate dehydrogenase during cell contact with and phagocytosis of serum-treated zymosan particles.
Localization (released) of beta-glucuronidase in neutrophils
8) Confidence 0.06 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 850132 Disease Relevance 0.07 Pain Relevance 0.04
Administration of both enantiomers also produced partial inhibition of beta-glucuronidase release into inflammatory exudate and of bradykinin-induced skin oedema.
Localization (release) of beta-glucuronidase in skin associated with pressure and volume under development, inflammation and bradykinin
9) Confidence 0.05 Published 1996 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 8971676 Disease Relevance 0.42 Pain Relevance 0.27
All the drugs inhibited the synthesis of serum TxB2 and exudate PGE2 and inhibited the release of beta-glucuronidase.
Localization (release) of beta-glucuronidase
10) Confidence 0.05 Published 1995 Journal Vet. Rec. Section Abstract Doc Link 8560701 Disease Relevance 0.28 Pain Relevance 0.26
Cocaine (10 mM) reduced beta-glucuronidase and lysozyme secretion to 4.3 +/- 0.7 and 13 +/- 2.2% controls, respectively; its IC50 was 4 mM.
Localization (secretion) of beta-glucuronidase associated with cocaine
11) Confidence 0.04 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2161879 Disease Relevance 0 Pain Relevance 0.82

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