INT197010

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.75
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP7A1) endoplasmic reticulum (CYP7A1)
Anatomy Link Frequency
bile 1
CYP7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 96 100.00 Very High Very High Very High
agonist 30 84.12 Quite High
Inflammation 10 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
nud 4 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Cholecystokinin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 74 95.76 Very High Very High Very High
Van Bogaert's Disease 6 85.52 High High
Gallbladder Disease 4 76.08 Quite High
Atherosclerosis 27 75.28 Quite High
Increased Venous Pressure Under Development 6 70.36 Quite High
Gallstones 8 68.72 Quite High
Hyperglycemia 6 68.08 Quite High
Repression 12 66.44 Quite High
Coronary Artery Disease 54 50.00 Quite Low
Impaired Glucose Tolerance 10 35.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies have shown that the activation of this enzyme may be only partially mediated by FXR (Kerr et al 2002) while other studies have suggested that the activation of CYP7A1 is independent of either LXR or FXR activity (Shibata et al 2007).
Positive_regulation (activation) of CYP7A1
1) Confidence 0.47 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.34 Pain Relevance 0.07
For example, activation of CYP7A1 is one of the most fundamental enzyme effects of BAS treatment.
Positive_regulation (activation) of CYP7A1
2) Confidence 0.47 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.37 Pain Relevance 0.08
Some reports suggest a transcriptional upregulation of Cyp7a1 upon PPAR?
Positive_regulation (upregulation) of Cyp7a1
3) Confidence 0.28 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.45 Pain Relevance 0.23
-hydroxylase (CYP7), responsible for catabolism of cholesterol as bile, is upregulated [3] as part of a compensatory mechanism in the liver.
Positive_regulation (upregulated) of CYP7 in bile associated with bile
4) Confidence 0.24 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.16 Pain Relevance 0.09
In particular, the upregulation of Cyp7a1 under fasting conditions and the downregulation of this enzyme in PPAR?
Positive_regulation (upregulation) of Cyp7a1
5) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.44 Pain Relevance 0.23

General Comments

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