INT197016

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.82
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (LDLR) small molecule metabolic process (LDLR) plasma membrane (LDLR)
lipid metabolic process (LDLR) lysosome (LDLR)
Anatomy Link Frequency
plasma 4
liver 4
hepatocytes 4
Blood 2
fibroblasts 2
LDLR (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 9 90.88 High High
Bile 12 80.56 Quite High
Pain 5 67.68 Quite High
imagery 6 61.04 Quite High
Potency 49 56.08 Quite High
Osteoarthritis 12 50.00 Quite Low
Inflammation 40 32.72 Quite Low
antagonist 76 5.00 Very Low Very Low Very Low
Angina 26 5.00 Very Low Very Low Very Low
local anesthetic 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 108 100.00 Very High Very High Very High
Hyperlipidemia 32 99.96 Very High Very High Very High
Disorder Of Lipid Metabolism 216 99.52 Very High Very High Very High
Weight Loss 12 99.40 Very High Very High Very High
Diabetes Mellitus 74 98.40 Very High Very High Very High
Congenital Anomalies 11 96.84 Very High Very High Very High
Disease 91 92.00 High High
Cardiovascular Disease 47 90.96 High High
Hyperlipoproteinemia Type Ii 11 90.96 High High
Impaired Glucose Tolerance 8 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also in our second project: the Israel Blood Pressure Control (IBPC) program [10], there was a significant increase in the percentage of patents defined as "controlled" in hypertension, Low Density Lipoprotein (LDL) levels and in the percentage of patients with diabetes.
Positive_regulation (increase) of Gene_expression (levels) of Low Density Lipoprotein in Blood associated with diabetes mellitus and hypertension
1) Confidence 0.50 Published 2007 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2217271 Disease Relevance 1.26 Pain Relevance 0.07
In addition, previous studies in our laboratory have shown that the decreases in LDL-C observed following a weight reduction program were correlated with increased expression of the LDL receptor in human mononuclear cells [5].
Positive_regulation (increased) of Gene_expression (expression) of LDL receptor in mononuclear cells associated with weight loss
2) Confidence 0.42 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.10 Pain Relevance 0
In patients with normal triglyceride and HDL-cholesterol levels but elevated LDL-cholesterol levels despite statin therapy several approaches are possible.
Positive_regulation (elevated) of Gene_expression (levels) of LDL-cholesterol associated with disorder of lipid metabolism
3) Confidence 0.35 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.41 Pain Relevance 0.04
Berberine may affect lipid levels by increasing expression of hepatic low density lipoprotein receptor [8].
Positive_regulation (increasing) of Gene_expression (expression) of low density lipoprotein receptor
4) Confidence 0.29 Published 2008 Journal Nutr J Section Body Doc Link PMC2409365 Disease Relevance 0.47 Pain Relevance 0.05
In subjects with familial hyperlipidemia, elevated blood oxLDL and LDL-cholesterol levels were associated with increased carotid intimal-media thickness.23 In two other studies, elevated plasma oxLDL levels were associated with increased carotid intimal-media thickness in asymptomatic subjects whose relatives had familial hypercholesterolemia and also in asymptomatic middle-aged males.24,25
Positive_regulation (elevated) of Gene_expression (levels) of LDL-cholesterol in plasma associated with hyperlipoproteinemia type ii and hyperlipidemia
5) Confidence 0.24 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.68 Pain Relevance 0
Since decreased cholesterol biosynthesis is associated with increased LDL-receptor expression in hepatocytes [8,9], SCP effects on serum LDL-C can be suggested as originating from increased LDL- binding, uptake or degradation, as demonstrated in studies measuring radiolabeled LDL on the surface of human fibroblasts [5].
Positive_regulation (increased) of Gene_expression (expression) of LDL-receptor in fibroblasts
6) Confidence 0.22 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2390548 Disease Relevance 0 Pain Relevance 0
In humans, data from clinical trials (REVERSAL, MIRACL) with aggressive LDL-cholesterol reduction also reported and unexpected increase in oxPL/apoB [36, 37].
Positive_regulation (increase) of Gene_expression (reduction) of LDL-cholesterol
7) Confidence 0.18 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3022166 Disease Relevance 0.62 Pain Relevance 0
Statins are a broadly used group of cholesterol-lowering agents that act by inhibiting the enzyme 3-hydroxy 3-methylglutaryl CoA (HMG CoA) reductase, which catalyzes the rate-limiting step in cholesterol biosynthesis [299,300]; therefore, statins reduce the concentration of downstream metabolic by-products including mevalonate, which in turn leads to increased LDL-receptor expression in hepatocytes and to increased LDL-C uptake from the circulation.
Positive_regulation (leads) of Gene_expression (expression) of LDL-receptor in hepatocytes
8) Confidence 0.17 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.76 Pain Relevance 0
Genetic variations in LDL receptor expression were shown to be associated with diminished statin response (i.e., diminished effects of statins on in vivo lipid reductions and on in vitro LDL receptor induction); and similarly, attenuated statin-mediated changes were observed in subjects with genetic mutations in HMG CoA reductase[20].
Positive_regulation (variations) of Gene_expression (expression) of LDL receptor
9) Confidence 0.17 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2992529 Disease Relevance 0 Pain Relevance 0.03
Pitavastatin showed more effective induction of LDL receptor expression than either atorvastatin or simvastatin.14 Pitavastatin induced expression of the LDL receptor more efficiently than the other statins and promoted the uptake of LDL from the blood to the liver to lower the serum LDL-C levels.
Positive_regulation (induction) of Gene_expression (expression) of LDL receptor in liver
10) Confidence 0.12 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.13 Pain Relevance 0.03
Statins are a broadly used group of cholesterol-lowering agents that act by inhibiting the enzyme 3-hydroxy 3-methylglutaryl CoA (HMG CoA) reductase, which catalyzes the rate-limiting step in cholesterol biosynthesis [299,300]; therefore, statins reduce the concentration of downstream metabolic by-products including mevalonate, which in turn leads to increased LDL-receptor expression in hepatocytes and to increased LDL-C uptake from the circulation.
Positive_regulation (increased) of Gene_expression (expression) of LDL-receptor in hepatocytes
11) Confidence 0.12 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.76 Pain Relevance 0
Pitavastatin showed more effective induction of LDL receptor expression than either atorvastatin or simvastatin.14 Pitavastatin induced expression of the LDL receptor more efficiently than the other statins and promoted the uptake of LDL from the blood to the liver to lower the serum LDL-C levels.
Positive_regulation (induced) of Gene_expression (expression) of LDL receptor in liver
12) Confidence 0.08 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.14 Pain Relevance 0.03
Elevated plasma levels of TG and dense LDL-cholesterol particles along with low levels of HDL-cholesterol constitute an atherogenic lipoprotein phenotype [45].
Positive_regulation (Elevated) of Gene_expression (levels) of LDL-cholesterol in plasma associated with disorder of lipid metabolism
13) Confidence 0.02 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.49 Pain Relevance 0

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