INT197024

Context Info Confidence 0.35 First Reported 2006 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 11 Total Number 14 Disease Relevance 10.84 Pain Relevance 0.52

Golgi apparatus (STIP1) nucleus (STIP1) protein complex (STIP1) response to stress (STIP1) cytoplasm (STIP1)

Anatomy Link Frequency male urethra 1 upper 1 STIP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 36 98.48 abdominal pain 11 90.20 Pain 20 86.40 Crohn's disease 4 5.00 Dysuria 4 5.00 Dismenorea 2 5.00 pain pelvic 2 5.00 fibrosis 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Infection 682 100.00 Reprotox - General 3 28 100.00 Reprotox - General 2 9 100.00 Reprotox - General 1 3 100.00 Cervical Cancer 10 99.84 Schistosomiasis 84 99.82 Stress Incontinence 25 99.72 Bacterial Vaginosis 20 98.98 INFLAMMATION 21 98.48 Papillomavirus Infection 64 98.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We applied the indirect costs per case of STI for cases averted by the interruption of STI transmission in the population.

STI Binding (interruption) of associated with infection

1) Confidence 0.35 Published 2008 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2426671 Disease Relevance 2.09 Pain Relevance 0

Being diagnosed with an STI could have negative impacts on respondents' sexual practices.

an STI Binding (diagnosed) of

2) Confidence 0.33 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2930645 Disease Relevance 0.52 Pain Relevance 0

The respondents' reports of very positive as well as quite negative experiences associated with STI providers, which were usually not determined by shared sex and age, points to the need for provider training.

STI Binding (associated) of

3) Confidence 0.33 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2930645 Disease Relevance 0.17 Pain Relevance 0

Respondents also described feeling ashamed at the thought of informing their parents and friends that they had been diagnosed with an STI.

an STI Binding (diagnosed) of

4) Confidence 0.33 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2930645 Disease Relevance 0.15 Pain Relevance 0

In the absence of information surrounding these symptoms, they often did not readily recognize them as being STI-related and assumed that they would resolve themselves with time as narrated below.

STI-related Neg (not) Binding (recognize) of

5) Confidence 0.29 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.74 Pain Relevance 0.18

We then used the 10th and 90th percentiles of these 50,000 simulations as the lower and upper bound values of the STI costs averted by STI program activities.

STI Binding (bound) of in upper associated with infection

6) Confidence 0.29 Published 2008 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2426671 Disease Relevance 0.98 Pain Relevance 0

Interviewer: And how do you think you would end up with this STI?

STI Binding (end) of

7) Confidence 0.22 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.70 Pain Relevance 0.11

Interviewer: Didn't your doctor talk with you about your STI, or about the STI risks?

STI Binding (talk) of

8) Confidence 0.22 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.76 Pain Relevance 0.11

Interviewer: Didn't your doctor talk with you about your STI, or about the STI risks?

STI Binding (about) of

9) Confidence 0.22 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1797160 Disease Relevance 0.76 Pain Relevance 0.11

A second key finding is the association of STI with a cluster of organisms not previously linked to the male urogenital tract: Sneathia, Gemella, Aerococcus, Anaerococcus, Prevotella and Veillonella, to name a few [9], [35], [41].

STI Binding (association) of associated with infection

10) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991352 Disease Relevance 0.30 Pain Relevance 0

Caution is clearly warranted in interpreting associations between characteristic microbiomes and STI; we cannot exclude other possible explanations for the patterns observed, such as long-term effects of undocumented antibiotic use [45].

STI Binding (associations) of associated with infection

11) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991352 Disease Relevance 0.69 Pain Relevance 0

To independently assess associations between STI and specific microbiomes the data were analyzed by un-weighted Unifrac PCA [26], [37].

STI Binding (associations) of associated with infection

12) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991352 Disease Relevance 0.49 Pain Relevance 0

These observations suggest the hypothesis that establishment of BV-like communities in the male urethra is similarly associated with STI risk.

STI Binding (associated) of in male urethra associated with bacterial vaginosis, stress incontinence and infection

13) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991352 Disease Relevance 0.88 Pain Relevance 0

Schistosomiasis and its association with ectopic pregnancy, infertility, abortion, and cervical lesions similar to STI or cervical cancer have been described in many case reports [4].

STI Binding (association) of associated with reprotox - general 2, cervical cancer, reprotox - general 3, reprotox - general 1 and schistosomiasis

14) Confidence 0.02 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1564144 Disease Relevance 1.63 Pain Relevance 0

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