INT19703

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.95
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
plasma 3
blood 1
platelets 1
red blood cell 1


Pain Term Frequency Confidence Heat
Angina 23 99.08 Very High Very High Very High
ischemia 15 98.72 Very High Very High Very High
aspirin 14 98.48 Very High Very High Very High
Inflammation 2 92.92 High High
Restless leg syndrome 2 87.72 High High
adenocard 2 81.76 Quite High
backache 1 62.16 Quite High
headache 1 60.64 Quite High
nud 1 50.24 Quite High
abdominal pain 1 48.32 Quite Low
Disease Term Frequency Confidence Heat
Cv General 3 Under Development 37 99.08 Very High Very High Very High
Coronary Artery Disease 7 98.72 Very High Very High Very High
Myocardial Infarction 33 97.28 Very High Very High Very High
Disorder Of Lipid Metabolism 1 93.48 High High
INFLAMMATION 2 92.92 High High
Atherosclerosis 1 89.84 High High
Acute Coronary Syndrome 32 88.40 High High
Sudden Death 6 88.00 High High
Increased Venous Pressure Under Development 2 87.72 High High
Arrhythmia Under Development 1 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction of myocardial ischemia induced by continuous infusion of heparin is associated with a decrease of fibrinopeptide A plasma levels, whereas the thromboxane B2 production by platelets seems to be irrelevant in order to obtain a reduction of myocardial ischemia.
Negative_regulation (decrease) of fibrinopeptide A in platelets associated with coronary artery disease and ischemia
1) Confidence 0.57 Published 1990 Journal Haemostasis Section Abstract Doc Link 2083863 Disease Relevance 0.82 Pain Relevance 0.57
During follow-up there was a significant decrease in the plasma levels of fibrinopeptide A both in patients with unstable angina (P < .001) and in those with myocardial infarction (P < .001), whereas no changes in plasma prothrombin fragment 1 + 2 or activated factor VII levels were observed.
Negative_regulation (decrease) of fibrinopeptide A in plasma associated with angina and myocardial infarction
2) Confidence 0.57 Published 1995 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 7583543 Disease Relevance 0.95 Pain Relevance 0.57
During infusion, thrombin-antithrombin III complex levels remained unchanged, whereas a significant 2.3-fold decrease in fibrinopeptide A concentrations was observed.
Negative_regulation (decrease) of fibrinopeptide A
3) Confidence 0.57 Published 1993 Journal J. Am. Coll. Cardiol. Section Body Doc Link 8459055 Disease Relevance 0 Pain Relevance 0
Hemostatic factors included fibrinogen, fibrinopeptide A, antithrombin III, factor VIII antigen, factor VIII coagulant, protein C, plasminogen, alpha 2 antiplasmin, euglobulin clot lysis time, tissue plasminogen activator before and after venous occlusion, and plasminogen activator inhibitor.
Negative_regulation (inhibitor) of fibrinopeptide A
4) Confidence 0.42 Published 1995 Journal Am. J. Cardiol. Section Abstract Doc Link 7618616 Disease Relevance 1.34 Pain Relevance 0.15
Levels of fibrinopeptide A, beta-thromboglobulin, platelet factor 4, thromboxane B2 and the platelet aggregates ratio in blood were similar between the 2 groups before, during and after PGI2 infusion.
Negative_regulation (Levels) of fibrinopeptide A in blood
5) Confidence 0.41 Published 1990 Journal Am. J. Cardiol. Section Abstract Doc Link 2109927 Disease Relevance 0.49 Pain Relevance 0.40
Ticlopidine and aspirin/dipyridamole, but not xanthinol nicotinate, improved platelet aggregation, reduced beta-thromboglobulin, platelet factor IV and fibrinopeptide A concentrations, and increased antithrombin III concentrations and red blood cell filterability.
Negative_regulation (reduced) of fibrinopeptide A in red blood cell associated with aspirin
6) Confidence 0.41 Published 1990 Journal J. Int. Med. Res. Section Abstract Doc Link 2147914 Disease Relevance 0.16 Pain Relevance 0.30
In addition, there is a dose-dependent relationship between bivalirudin and a decrease in plasma concentrations of fibrinopeptide A (a marker of fibrinogen conversion) (Topol et al 1993) and inhibition of plasminogen activator inhibitor activity (Shen et al 1997).
Negative_regulation (decrease) of fibrinopeptide A in plasma
7) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515410 Disease Relevance 0.83 Pain Relevance 0.23
We measured the plasma levels of prothrombin fragment 1+2, fibrinopeptide A, and antithrombin III in 64 consecutive patients with unstable angina or myocardial infarction receiving intravenous heparin.
Negative_regulation (measured) of fibrinopeptide A in plasma associated with angina and myocardial infarction
8) Confidence 0.18 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9261263 Disease Relevance 0.36 Pain Relevance 0.10

General Comments

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