INT197030

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 11.50
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
kidney 3
granulocytes 1
aorta 1
brainstem 1
lung 1
Ncf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 408 98.72 Very High Very High Very High
medulla 35 98.52 Very High Very High Very High
gABA 70 92.64 High High
rheumatoid arthritis 108 88.24 High High
Etanercept 36 87.92 High High
methotrexate 36 86.72 High High
fibrosis 18 83.60 Quite High
antagonist 30 74.40 Quite High
Inflammation 160 73.96 Quite High
depression 5 68.40 Quite High
Disease Link Frequency Relevance Heat
Chronic Renal Failure 185 100.00 Very High Very High Very High
Sprains And Strains 16 99.98 Very High Very High Very High
Hyperoxia 46 98.80 Very High Very High Very High
Arthritis 408 98.72 Very High Very High Very High
Hypertension 156 91.72 High High
Stress 131 89.88 High High
Disease 148 88.72 High High
Rheumatoid Arthritis 108 88.24 High High
Injury 31 86.80 High High
Coronary Heart Disease 27 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since it has been shown that one allele of Ncf1E3 is enough to restore the oxidative burst and to prevent arthritis in DA.Ncf1DA rats [7], we used a DA double congenic rat strain expressing not only Ncf1E3/DA but also a congenic fragment on Chromosome 6 allowing arthritis development [12].
Gene_expression (expressing) of Ncf1E3 associated with sprains and strains and arthritis
1) Confidence 0.78 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 1.11 Pain Relevance 0.39
Next we wanted to investigate whether rats expressing the Ncf1E3 allele could be treated successfully with phytol.
Gene_expression (expressing) of Ncf1E3
2) Confidence 0.78 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 1.16 Pain Relevance 0.41
The beneficial effects of phytol were seen not only in rats bred with a form of Ncf1 that produces abnormally low amounts of ROS, but also in rats whose granulocytes produce normal oxidative bursts.
Gene_expression (produces) of Ncf1 in granulocytes
3) Confidence 0.68 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1564167 Disease Relevance 1.00 Pain Relevance 0.56
Treatment with oxidative burst inducers was thus far done by increasing ROS production in DA.Ncf1DA rats.
Gene_expression (rats) of Ncf1DA
4) Confidence 0.59 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 1.20 Pain Relevance 0.44
Furthermore, we demonstrated that aldosterone activated NAD(P)H oxidase and increased the expression of membrane-bound elements (p22phox and gp91phox) and cytosolic components (p47phox) of the enzyme, which may be linked to cardio-vascular-renal damage.
Gene_expression (expression) of p47phox
5) Confidence 0.41 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.59 Pain Relevance 0.03
According to the real-time PCR, the level of p47phox and gp91phox gene expression in the RVLM in the CRF group was significantly higher than in the C group ((p47phox-CRF, 33.07 ± 5.47 and C, 1.13 ± 0.09 AU; P < .004) and (gp91phox, 14.51 ± 1.49 and C, 1.21 ± 0.28 AU; P < .001)), as shown in Figures 2(b) and 2(c).

3.3.

Gene_expression (expression) of p47phox associated with chronic renal failure
6) Confidence 0.40 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 1.24 Pain Relevance 0.12
In kidney, aldosterone-salt rats showed significantly higher p47phox, gp91phox, and p22phox expression than that of control rats.
Gene_expression (expression) of p47phox in kidney
7) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0
Aortic expression of the subunits p47phox, gp91phox, and p22phox increased in aldosterone-infused rats by 5.5, 4.7, and 3.2-fold, respectively, which was decreased completely by spironolactone and partially by losartan and apocynin.
Gene_expression (expression) of p47phox
8) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2610641 Disease Relevance 0.32 Pain Relevance 0
Spironolactone, losartan, and apocynin inhibited the aldosterone-stimulated p47phox expression in kidney (Fig. 4B).


Gene_expression (expression) of p47phox in kidney
9) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.24 Pain Relevance 0.04
The p47phox expression enhanced in kidney of aldosterone infused rats compared with that of control rats.
Gene_expression (expression) of p47phox in kidney
10) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.20 Pain Relevance 0.03
The aldosterone-induced p47phox overexpression was prevented by spironolactone, and partially by losartan and apocynin.
Gene_expression (overexpression) of p47phox
11) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.13 Pain Relevance 0.03
Increased expression of p47phox in aldosterone-infused rat by immunohistochemistry
Gene_expression (expression) of p47phox
12) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0
The p22phox may individually interact with cytosolic regulatory elements, p47phox and Rac-1, and therefore, both increased expression of p22phox and p47phox will lead to activation of the enzyme.
Gene_expression (expression) of p47phox
13) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.23 Pain Relevance 0
In the present study, increased expression of the p67phox protein was observed both in the cytosolic and membrane fraction in HC, and G-CSF treatment significantly attenuated hyperoxia-induced NADPH oxidase activation as evidenced by reduced membrane translocation of the p67phox in the lung tissue.
Gene_expression (expression) of p67phox in lung associated with hyperoxia
14) Confidence 0.37 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.72 Pain Relevance 0
PCR was performed with primers selective for AT1 receptor, p47phox, and gp91phox (Table 1).
Gene_expression (selective) of p47phox
15) Confidence 0.34 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0 Pain Relevance 0
When NADPH oxidase is activated, expression and membrane translocation of a cytosolic subunit of NADPH oxidase p67phox is increased.
Gene_expression (expression) of p67phox
16) Confidence 0.32 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.51 Pain Relevance 0
In the present study, we found a reduction in the mRNA AT1 expression in the brainstem tissue in CRF rats accompanied by a significant increase in the level of p47phox and gp91phox gene expression in the RVLM compared to C group.
Gene_expression (expression) of p47phox in brainstem associated with medulla and chronic renal failure
17) Confidence 0.31 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.76 Pain Relevance 0.34
Therefore, the first aim of the present study was to quantify the NADPH p47phox and gp91phox subunits expression within the RVLM.
Gene_expression (expression) of p47phox
18) Confidence 0.31 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.86 Pain Relevance 0.07
According to the real-time PCR, the level of p47phox and gp91phox gene expression in the RVLM in the CRF group was significantly higher than in the C group ((p47phox-CRF, 33.07 ± 5.47 and C, 1.13 ± 0.09 AU; P < .004) and (gp91phox, 14.51 ± 1.49 and C, 1.21 ± 0.28 AU; P < .001)), as shown in Figures 2(b) and 2(c).

3.3.

Gene_expression (expression) of p47phox associated with chronic renal failure
19) Confidence 0.30 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 1.26 Pain Relevance 0.12
Aldosterone-salt rats showed significantly higher p47phox and gp91phox expression in aorta than that of control rats.
Gene_expression (expression) of p47phox in aorta
20) Confidence 0.16 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0

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