INT197032

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.84
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
brain 1
neutrophil 1
Ncf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 102 99.96 Very High Very High Very High
fibrosis 3 97.20 Very High Very High Very High
Inflammation 34 95.00 High High
rheumatoid arthritis 27 90.20 High High
antagonist 9 80.32 Quite High
cytokine 4 79.04 Quite High
Etanercept 9 77.88 Quite High
Kinase C 10 75.28 Quite High
methotrexate 9 71.64 Quite High
Bioavailability 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 102 99.96 Very High Very High Very High
Disease 38 99.50 Very High Very High Very High
Stress 23 98.04 Very High Very High Very High
Fibrosis 4 97.20 Very High Very High Very High
Autoimmune Disease 5 96.80 Very High Very High Very High
Coronary Heart Disease 4 96.68 Very High Very High Very High
INFLAMMATION 34 95.00 High High
Diabetes Mellitus 29 94.04 High High
Rheumatoid Arthritis 27 90.20 High High
Pressure And Volume Under Development 21 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, neutrophil cytosolic factor 1 (Ncf1) was identified by positional cloning as a gene controlling arthritis severity in rats [7].
Regulation (controlling) of Ncf1 in neutrophil associated with arthritis
1) Confidence 0.45 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 1.21 Pain Relevance 0.51
Evidence has been accumulated to indicate that oxidative stress and inflammation mediate a decrease in the eGFR (estimated glomerular filtration rate) of the kidney, in which an increase in ET-1 is a dominant factor for such prediction.19 There is also a link of an early impairment of Alzheimer’s disease with an upregulation of regulatory subunit p47phox and the catalytic subunit gp91phox in vulnerable brain regions, relevant to vascular endothelial dysfunction of the cerebro-artery in the brain.20

Diabetic vasculopathy

Regulation (regulatory) of p47phox in brain associated with stress, inflammation, diabetes mellitus and disease
2) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.26 Pain Relevance 0.22
Our present results demonstrate a critical role of NAD(P)H oxidase and its subunits, p47phox, gp91phox, and p22phox for the vascular oxidant stress response to aldosterone.
Regulation (role) of p47phox associated with stress
3) Confidence 0.07 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.37 Pain Relevance 0.05

General Comments

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