INT197045

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.32
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (PPIB) isomerase activity (PPIB) protein folding (PPIB)
endoplasmic reticulum (PPIB)
Anatomy Link Frequency
internal 2
PPIB (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 1 92.68 High High
palliative 10 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 170 99.26 Very High Very High Very High
Fracture Healing 64 94.72 High High
Osteoporosis 3 89.04 High High
Metastasis 65 87.12 High High
Cancer 140 73.12 Quite High
Recurrence 50 59.44 Quite High
Second Primary Neoplasms 5 58.44 Quite High
Death 5 53.24 Quite High
Hematoma 1 29.88 Quite Low
Disease 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The medians used corresponded to a PAI-1/PPIB and a uPA/PPIB expression ratio of 0.25 and 2.12 respectively.
Gene_expression (expression) of PPIB
1) Confidence 0.70 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.42 Pain Relevance 0
The quantification of uPA and PAI-1 mRNA levels was carried out with regard to the cyclophilin B (PPIB) housekeeping gene expression, according to the LightCycler™ Relative Quantification Software instructions (Roche Diagnostics, Mannheim, Germany).
Gene_expression (expression) of cyclophilin B
2) Confidence 0.61 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.05 Pain Relevance 0
The quantification of uPA and PAI-1 mRNA levels was carried out with regard to the cyclophilin B (PPIB) housekeeping gene expression, according to the LightCycler™ Relative Quantification Software instructions (Roche Diagnostics, Mannheim, Germany).
Gene_expression (expression) of PPIB
3) Confidence 0.61 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.05 Pain Relevance 0
Real-time quantitative RT-PCR was carried out to measure uPA and PAI-1 mRNA expression between relapsed and non-relapsed breast cancers on the 87 samples studied using the cyclophilin B (PPIB) gene, known to be stably expressed in breast tissues, as an internal control [20].
Gene_expression (expressed) of cyclophilin B in internal associated with breast cancer
4) Confidence 0.54 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.73 Pain Relevance 0
Real-time quantitative RT-PCR was carried out to measure uPA and PAI-1 mRNA expression between relapsed and non-relapsed breast cancers on the 87 samples studied using the cyclophilin B (PPIB) gene, known to be stably expressed in breast tissues, as an internal control [20].
Gene_expression (expressed) of PPIB in internal associated with breast cancer
5) Confidence 0.54 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.73 Pain Relevance 0
Additionally, we showed differential expression for NSEP1, PPIB, and RARA, for which to the best of our knowledge no previous information about differential expression during bone development or fracture healing was available.



Gene_expression (expression) of PPIB associated with fracture healing
6) Confidence 0.09 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.35 Pain Relevance 0.05

General Comments

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