INT197092

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.78
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, VEGFA) extracellular region (TNF, VEGFA) intracellular (TNF)
extracellular matrix organization (TNF) cytoplasm (VEGFA) signal transduction (TNF)
Anatomy Link Frequency
lymphatic vessels 3
TNF (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 52 100.00 Very High Very High Very High
cytokine 49 100.00 Very High Very High Very High
Inflammatory mediators 4 97.28 Very High Very High Very High
antagonist 7 94.44 High High
Arthritis 34 89.64 High High
rheumatoid arthritis 20 67.20 Quite High
imagery 3 59.80 Quite High
Infliximab 10 50.00 Quite Low
Osteoarthritis 9 5.00 Very Low Very Low Very Low
Inflammatory stimuli 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 68 100.00 Very High Very High Very High
Adhesions 14 95.16 Very High Very High Very High
Rheumatoid Arthritis 50 89.64 High High
Targeted Disruption 6 85.16 High High
Helminth Infection 110 84.92 Quite High
Death 16 71.04 Quite High
Cancer 21 68.40 Quite High
Hydrocele 68 65.76 Quite High
Disease Progression 4 64.84 Quite High
Lymphedema 175 59.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, VEGF is known to mediate angiogenesis and is regulated by pro-inflammatory cytokines such as TNF?.
TNF Regulation (regulated) of VEGF associated with inflammation and cytokine
1) Confidence 0.21 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564801 Disease Relevance 0.43 Pain Relevance 0.27
In an animal model of airway inflammatory angiogenesis, VEGF independent angiogenic effects of TNF-?
TNF Neg (independent) Regulation (effects) of VEGF associated with inflammation
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779850 Disease Relevance 0.53 Pain Relevance 0.27
This raises the possibility that proinflammatory cytokines such as TNF and IL-1B induced by Wolbachia could affect lymphatic vessels via VEGF-C and its receptor sVEGFR-3.
TNF Regulation (affect) of VEGF in lymphatic vessels associated with cytokine
3) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.65 Pain Relevance 0.19
, TNF and IL-17 (42), suggesting that pro-inflammatory cytokines affect the lymphatic vessels via VEGF-A and VEGF-C (43,44).
TNF Regulation (affect) of VEGF in lymphatic vessels associated with inflammation and cytokine
4) Confidence 0.00 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2784903 Disease Relevance 0.58 Pain Relevance 0.25
, TNF and IL-17 (42), suggesting that pro-inflammatory cytokines affect the lymphatic vessels via VEGF-A and VEGF-C (43,44).
TNF Regulation (affect) of VEGF in lymphatic vessels associated with inflammation and cytokine
5) Confidence 0.00 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2784903 Disease Relevance 0.58 Pain Relevance 0.25

General Comments

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