INT197103

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.08
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FLT4) plasma membrane (FLT4) nucleus (FLT4)
cytoplasm (FLT4)
Anatomy Link Frequency
liver 2
keratinocytes 1
FLT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 21 71.04 Quite High
dexamethasone 10 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibromyalgia 2 100.00 Very High Very High Very High
Cancer 55 99.20 Very High Very High Very High
Targeted Disruption 6 98.44 Very High Very High Very High
Lymphedema 77 92.64 High High
Solid Tumor 17 90.68 High High
Hypoxia 8 81.16 Quite High
Adenocarcinoma 2 79.20 Quite High
Glioma 2 74.04 Quite High
Necrosis 3 72.24 Quite High
Hypoglycemia 2 62.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this genetic model, sVEGFR-3 is secreted at high levels by basal epidermal keratinocytes and binds the lymphangiogenesis factors VEGF-C and VEGF-D, thereby preventing them from activating membrane-bound VEGFR-3 on lymphatic endothelium [36].
sVEGFR-3 Binding (binds) of in keratinocytes
1) Confidence 0.29 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.79 Pain Relevance 0.07
VEGF has a key, rate-limiting role in promoting tumor angiogenesis and exerts its effects by binding to one of three tyrosine kinase receptors (Figure 1): VEGF receptor-1 (VEGFR-1; fms-like tyrosine kinase-1, Flt-1), VEGFR-2 (human kinase domain region, KDR/murine fetal liver kinase-1, Flk-1), and VEGFR-3 (Flt-4).
Flt-4 Binding (binding) of in liver associated with fibromyalgia and cancer
2) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.15 Pain Relevance 0.03
VEGF has a key, rate-limiting role in promoting tumor angiogenesis and exerts its effects by binding to one of three tyrosine kinase receptors (Figure 1): VEGF receptor-1 (VEGFR-1; fms-like tyrosine kinase-1, Flt-1), VEGFR-2 (human kinase domain region, KDR/murine fetal liver kinase-1, Flk-1), and VEGFR-3 (Flt-4).
VEGFR-3 Binding (binding) of in liver associated with fibromyalgia and cancer
3) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.15 Pain Relevance 0.03

General Comments

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