INT197104

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.45
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FLT4) plasma membrane (FLT4) nucleus (FLT4)
cytoplasm (FLT4)
Anatomy Link Frequency
stems 4
lymphatic vessels 2
FLT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 52 94.28 High High
Inflammation 4 27.84 Quite Low
Paracetamol 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
drug abuse 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphedema 308 99.72 Very High Very High Very High
Targeted Disruption 16 99.50 Very High Very High Very High
Helminth Infection 240 97.36 Very High Very High Very High
Death 16 82.24 Quite High
Filariasis 24 82.04 Quite High
Disease Progression 4 80.64 Quite High
Lymphatic Filariasis 92 78.80 Quite High
Cancer 28 76.52 Quite High
Disease 72 63.72 Quite High
Necrosis 4 55.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional evidence for the role of VEGF-C/VEGF-D/VEGFR-3 in the pathogenesis of lymphatic dilation and lymphedema stems from experimental studies in transgenic mice with skin specific overexpression of soluble VEGFR-3 (sVEGFR-3) using a keratin 14 transgenic promoter [36].
Positive_regulation (overexpression) of Gene_expression (overexpression) of sVEGFR-3 in stems associated with targeted disruption and lymphedema
1) Confidence 0.56 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.76 Pain Relevance 0.06
Additional evidence for the role of VEGF-C/VEGF-D/VEGFR-3 in the pathogenesis of lymphatic dilation and lymphedema stems from experimental studies in transgenic mice with skin specific overexpression of soluble VEGFR-3 (sVEGFR-3) using a keratin 14 transgenic promoter [36].
Positive_regulation (overexpression) of Gene_expression (overexpression) of VEGFR-3 in stems associated with targeted disruption and lymphedema
2) Confidence 0.47 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.76 Pain Relevance 0.05
Here, we have provided circumstantial evidence for both, in a series of events: the lymphatic dilation may be partly caused by overexpression of VEGF-C/sVEGFR-3 produced by the endothelial cells of the lymphatic vessels of the host in response to products of the adult worm that are reduced by doxycycline.
Positive_regulation (overexpression) of Gene_expression (produced) of sVEGFR-3 in lymphatic vessels associated with helminth infection
3) Confidence 0.41 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.77 Pain Relevance 0
Although both microfilaremic and lymphedema patients had elevated VEGF-C and sVEGFR-3 levels, those of sVEGFR-3 were yet significantly higher in lymphedema patients compared to non-lymphedema patients that are microfilaremic (p = 0.0024, Figure 4).
Positive_regulation (elevated) of Gene_expression (levels) of sVEGFR-3 associated with lymphedema
4) Confidence 0.41 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 1.15 Pain Relevance 0.08

General Comments

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