INT197143

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 9.41
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Renbp)
Anatomy Link Frequency
bile duct 1
tears 1
skull 1
neurons 1
suprachiasmatic nucleus 1
Renbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 3 99.54 Very High Very High Very High
Arthritis 30 99.48 Very High Very High Very High
Inflammation 10 98.58 Very High Very High Very High
cytokine 1 96.96 Very High Very High Very High
GABAergic 42 91.84 High High
cINOD 1 91.40 High High
metalloproteinase 68 88.40 High High
Pain 20 85.32 High High
GABA receptor 6 80.08 Quite High
Somatosensory cortex 12 75.76 Quite High
Disease Link Frequency Relevance Heat
Uterine Fibroids 188 100.00 Very High Very High Very High
Diabetes Mellitus 78 100.00 Very High Very High Very High
Gestational Diabetes 24 100.00 Very High Very High Very High
Hyperplasia 9 99.88 Very High Very High Very High
Osteoarthritis 5 99.48 Very High Very High Very High
Cleidocranial Dysplasia 10 99.00 Very High Very High Very High
Vasculitis 8 98.58 Very High Very High Very High
Injury 80 97.20 Very High Very High Very High
Osteochondrodysplasias 4 97.08 Very High Very High Very High
Achondroplasia 22 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Older people are paradoxically often excluded from studies on health care use, since the need for health care services increases with age.
Positive_regulation (increases) of age
1) Confidence 0.33 Published 2006 Journal BMC Health Serv Res Section Body Doc Link PMC1569836 Disease Relevance 0.28 Pain Relevance 0
It is well documented that the physical health status decreases with increasing age in the general population [27].
Positive_regulation (increasing) of age
2) Confidence 0.26 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1838413 Disease Relevance 1.03 Pain Relevance 0.21
There is a significant interaction of the factors age and amplitude for ISIs 35 and 200 ms, indicating that the amplitudes of A1 and A2 diverge as age increases (35 ms: F1,176 = 13.719, P < 0.001; 200 ms: F1,173 = 10.449, P < 0.001).
Positive_regulation (increases) of age
3) Confidence 0.21 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2852507 Disease Relevance 0.07 Pain Relevance 0
Literature describes premature degenerative arthritis as a common problem with increasing age in some of the skeletal dysplasia diagnoses, i.e. pseudoachondroplasia, multiple epiphyseal dysplasia [4,5,7].
Positive_regulation (increasing) of age associated with osteochondrodysplasias, cleidocranial dysplasia, osteoarthritis and arthritis
4) Confidence 0.18 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1838413 Disease Relevance 1.35 Pain Relevance 0.24
If this is the case, one would expect to find a strong correlation between age-related enlargement of RFs and a reduction of PPS.
Positive_regulation (enlargement) of age
5) Confidence 0.15 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2852507 Disease Relevance 0.07 Pain Relevance 0.13
At all ISIs tested, the mean amplitude ratios of the neurons recorded in old animals were higher than those of the young animals, indicating less PPS in old age (Fig. 2).
Positive_regulation (indicating) of age in neurons
6) Confidence 0.15 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2852507 Disease Relevance 0 Pain Relevance 0.07
The age-adjusted increase in incidence that has been observed in several countries over the last 50 years appears to have levelled off in some of these countries, especially in Europe and the US.
Positive_regulation (increase) of age-adjusted
7) Confidence 0.13 Published 2011 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC3004072 Disease Relevance 0.75 Pain Relevance 0.04
Furthermore, humans exhibit sexually dimorphic patterns of suprachiasmatic nucleus (SCN) neuron deterioration, with women showing no change throughout adulthood while men exhibit complex and fluctuating patterns with increasing age [51].
Positive_regulation (increasing) of age in suprachiasmatic nucleus
8) Confidence 0.12 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.13 Pain Relevance 0
Since data from all age groups were included in the pathway analysis, the results are generic to the entire life cycle and do not provide meaningful insight into specific periods of the life cycle which may feature unique expression patterns that would underlie age-related susceptibilities.
Positive_regulation (underlie) of age
9) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.76 Pain Relevance 0
Also, male predominant findings of bile duct hyperplasia with increasing incidence with age were observed.
Positive_regulation (increasing) of age in bile duct associated with bile and hyperplasia
10) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.26 Pain Relevance 0.05
P1 rats received the freezing probe for 5 seconds, while the P3 animals were given 7 seconds and the P5 rats a 10 second lesion (to compensate for age-related increases in thickness of the skull).
Positive_regulation (increases) of age in skull
11) Confidence 0.09 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2204005 Disease Relevance 0.07 Pain Relevance 0.10
Results show an age of treatment by treatment interaction, indicating that as the age at injury moves from P5 to P1 the corpus callosum becomes smaller.
Positive_regulation (show) of age in corpus callosum associated with injury
12) Confidence 0.09 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2204005 Disease Relevance 0.16 Pain Relevance 0
AGE-mediated cross-link formation in proteins such as collagen may result not only in stiffening of the arteries, but also in increased extracellular matrix formation and increased vascular inflammation, which results in increased risk of neointimal proliferation.7)19-21) AGE accumulation and formation of cross links are associated with increased proinflammatory cytokine levels and increased expression of AGE receptors (RAGEs), resulting in increased vascular inflammation.16)21)22)
Positive_regulation (accumulation) of AGE in extracellular matrix associated with inflammation, vasculitis and cytokine
13) Confidence 0.09 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.97 Pain Relevance 0.14
This value, 1.008, represents the value of a 1 U/ml increase of the serum AGE level; small vessel caliber (post MLD ?
Positive_regulation (increase) of AGE
14) Confidence 0.07 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2823061 Disease Relevance 1.31 Pain Relevance 0
However, because fibroid incidence increases strongly with age, we only considered diagnoses by 35 years of age to reduce misclassification in the noncase group.
Positive_regulation (increases) of age associated with uterine fibroids
15) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 0.87 Pain Relevance 0
LHB degeneration may be a result of age-dependent shoulder pathology as it occurs in the presence or absence of cuff tears.
Positive_regulation (result) of age in tears
16) Confidence 0.04 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.58 Pain Relevance 0.34
Five of the 14 early-life factors we examined were associated with more than a 20% increase in risk of early fibroid diagnosis (DES, prepregnancy diabetes, gestational diabetes, soy formula, and gestational age at birth) (Table 2).
Positive_regulation (increase) of age associated with uterine fibroids, gestational diabetes and diabetes mellitus
17) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 0.76 Pain Relevance 0

General Comments

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