INT197163

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.41
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CRAMP1L) DNA binding (CRAMP1L)
CRAMP1L (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 96.68 Very High Very High Very High
headache 3 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 96 99.90 Very High Very High Very High
Disease 22 99.22 Very High Very High Very High
Hypersensitivity 31 93.36 High High
Eczema 30 92.00 High High
Toxicity 36 90.36 High High
General Immunology 3 86.72 High High
Lymphatic System Cancer 18 81.28 Quite High
Genetic Predisposition To Disease 1 75.00 Quite High
Hodgkin's Disease 15 73.60 Quite High
Leukemia 3 73.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, a better mechanistic understanding of this disease may help clarify how these tumors are associated with TCE exposure.


TCE Binding (associated) of associated with cancer and disease
1) Confidence 0.26 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570079 Disease Relevance 1.36 Pain Relevance 0
TCE is metabolized primarily by two pathways: oxidation via cytochrome P450s and conjugation with glutathione via glutathione S-transferase.
TCE Binding (metabolized) of
2) Confidence 0.23 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570079 Disease Relevance 0.09 Pain Relevance 0
TCE and two of its key metabolites, TCA and DCA, have been characterized as weak peroxisome proliferators.
TCE Binding (metabolites) of
3) Confidence 0.23 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570079 Disease Relevance 0.29 Pain Relevance 0.10
Trichloroethylene (TCE) is used extensively as an industrial solvent and has been recognized as one of the major environmental pollutants.
TCE Binding (recognized) of
4) Confidence 0.05 Published 2007 Journal Environ Health Perspect Section Abstract Doc Link PMC2072824 Disease Relevance 0.67 Pain Relevance 0

General Comments

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