INT197167

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 9.51
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
skin 2
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 44 100.00 Very High Very High Very High
Inflammation 437 96.48 Very High Very High Very High
Inflammatory stimuli 7 84.88 Quite High
cytokine 106 84.44 Quite High
agonist 259 75.20 Quite High
Kinase C 18 72.00 Quite High
fibrosis 17 63.00 Quite High
psoriasis 7 61.12 Quite High
dexamethasone 28 50.00 Quite Low
Inflammatory response 34 49.72 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 100 99.84 Very High Very High Very High
Skin Cancer 32 99.70 Very High Very High Very High
Cancer 552 99.36 Very High Very High Very High
Obesity 127 98.16 Very High Very High Very High
Brain Disease 3 97.12 Very High Very High Very High
Colon Cancer 113 96.52 Very High Very High Very High
INFLAMMATION 488 96.48 Very High Very High Very High
Breast Cancer 20 96.36 Very High Very High Very High
Metabolic Syndrome 16 95.96 Very High Very High Very High
Glioma 3 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
increase the production and the nuclear localization of the PPAR?
Positive_regulation (increase) of Localization (localization) of PPAR
1) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.15 Pain Relevance 0.04
The physiological role of PIAS1 is to facilitate the localization of PPAR-?
Positive_regulation (facilitate) of Localization (localization) of PPAR
2) Confidence 0.61 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.18 Pain Relevance 0.12
These p160 family members are among the coactivators considered important for nuclear receptor function, but the in vivo results indicate their redundancy at least for PPAR?
Positive_regulation (least) of Localization (redundancy) of PPAR
3) Confidence 0.50 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.13 Pain Relevance 0
These p160 family members are among the coactivators considered important for nuclear receptor function, but the in vivo results indicate their redundancy at least for PPAR?
Positive_regulation (indicate) of Localization (redundancy) of PPAR
4) Confidence 0.50 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.13 Pain Relevance 0
effect of candidates are dependent on the retention of SRC-1 by the GST-PPAR
Positive_regulation (dependent) of Localization (retention) of GST-PPAR
5) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0
generate these lipid signals from fatty acids, which also serve as PPAR
Positive_regulation (as) of Localization (serve) of PPAR
6) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.06 Pain Relevance 0.03
did not prevent the development of UV- or DMBA/TPA-induced skin tumors [89], despite increased susceptibility of PPAR?
Positive_regulation (increased) of Localization (susceptibility) of PPAR in skin associated with skin cancer
7) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 1.12 Pain Relevance 0.18
influence of increased PPAR?
Positive_regulation (increased) of Localization (influence) of PPAR
8) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.23 Pain Relevance 0
Increased serum triglycerides, cholesterol, and phosholipids were elevated in aged PPAR?
Positive_regulation (elevated) of Localization (aged) of PPAR
9) Confidence 0.44 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.86 Pain Relevance 0.11
control are important to glucose uptake, lipid metabolism and storage, as well as adipogenesis, explaining the ability of PPAR?
Positive_regulation (important) of Localization (ability) of PPAR
10) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 0.63 Pain Relevance 0.15
locus causes absence of PPAR-?
Positive_regulation (causes) of Neg (absence) Localization (absence) of PPAR
11) Confidence 0.41 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.54 Pain Relevance 0
translocation in response to a selective PPAR?
Positive_regulation (response) of Localization (translocation) of PPAR
12) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266973 Disease Relevance 0.06 Pain Relevance 0
active form of PPAR?
Positive_regulation (active) of Localization (form) of PPAR
13) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.19 Pain Relevance 0
2, in which the potent viral transcriptional activator VP16 is fused to PPAR-?
Positive_regulation (activator) of Localization (fused) of PPAR
14) Confidence 0.30 Published 2007 Journal Respir Res Section Body Doc Link PMC2231357 Disease Relevance 0 Pain Relevance 0
supporting the use of PPAR-?
Positive_regulation (supporting) of Localization (use) of PPAR
15) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.98 Pain Relevance 0.11
signal through activation of PPARs, with reports of both PPAR?
Positive_regulation (activation) of Localization (reports) of PPAR
16) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.53 Pain Relevance 0.03
These are supported by conventional NSAIDs activates PPAR?
Positive_regulation (activates) of Localization (supported) of PPAR associated with cinod
17) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422868 Disease Relevance 1.27 Pain Relevance 0.42
a signal-mediated translocation of PPAR?
Positive_regulation (mediated) of Localization (translocation) of PPAR
18) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.46 Pain Relevance 0

General Comments

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