INT197206

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.13
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik1) plasma membrane (Grik1)
Anatomy Link Frequency
neurons 2
Grik1 (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 57 99.60 Very High Very High Very High
antagonist 8 97.00 Very High Very High Very High
gABA 12 95.52 Very High Very High Very High
Trk A 1 92.12 High High
Spinal cord 21 88.52 High High
Action potential 5 85.00 Quite High
spinal dorsal horn 5 72.16 Quite High
nociceptor 18 59.60 Quite High
Glutamate receptor 2 56.64 Quite High
GABAergic 13 48.44 Quite Low
Disease Link Frequency Relevance Heat
Nociception 15 65.12 Quite High
Targeted Disruption 5 62.92 Quite High
Pain 8 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Ganglion Cysts 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When expressed as "fold-change in expression" the SAGE results demonstrate a down regulation of Grik1, Dock4 and Crip2 expression between P0 WT and P0 Trka-/- DRG of about 18, 6 and 3 fold respectively, while QRT-PCR provided an expression ratio between P0 WT and P0 Trka-/- DRG of 17, 4 and 4 fold respectively.


Regulation (regulation) of Gene_expression (expression) of Grik1
1) Confidence 0.39 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.13 Pain Relevance 0.16
Mechanism for GluR5 modulation of inhibitory transmission in SG neurons
Regulation (Mechanism) of Gene_expression (modulation) of GluR5 in neurons associated with substantia gelatinosa
2) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.55

General Comments

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