INT197209

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.36
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik1) plasma membrane (Grik1)
Anatomy Link Frequency
neurons 6
Grik1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 38 100.00 Very High Very High Very High
Somatostatin 3 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
substantia gelatinosa 171 99.88 Very High Very High Very High
Glutamate receptor 1 99.68 Very High Very High Very High
GABA receptor 1 99.60 Very High Very High Very High
GABAergic 39 99.40 Very High Very High Very High
Glutamate 9 94.56 High High
Spinal cord 57 92.80 High High
Disease Link Frequency Relevance Heat
Nociception 22 84.32 Quite High
Targeted Disruption 30 75.28 Quite High
Neurodegenerative Disease 6 75.12 Quite High
Adhesions 1 67.36 Quite High
Ganglion Cysts 70 53.88 Quite High
Pain 10 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low
Epilepsy 3 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both GABAergic and glycinergic release were enhanced by GluR5 activation in SG neurons
Positive_regulation (enhanced) of Positive_regulation (activation) of GluR5 in neurons associated with substantia gelatinosa and gabaergic
1) Confidence 0.50 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.67
We found that the activation of GluR5 by ATPA increased the frequency of sIPSCs in all SG neurons tested.
Positive_regulation (increased) of Positive_regulation (activation) of GluR5 in neurons associated with substantia gelatinosa
2) Confidence 0.44 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.40
Activation of presynaptic GluR5 increases the frequency of mIPSCs in SG neurons
Positive_regulation (increases) of Positive_regulation (Activation) of GluR5 in neurons associated with substantia gelatinosa
3) Confidence 0.44 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.29
Among mediators of neurotransmission, multiple glutamate receptors (Gria3, Gria4, Grik1), a GABA transporter (Slc6a1), a serotonin receptor (Htr3a) and the neuropeptide somatostatin are increased, while a GABA receptor (Gabra2) and neuropeptides with specific sensory roles (Galanin, Adcyap1/PACAP) are decreased.
Positive_regulation (increased) of Positive_regulation (increased) of Grik1 associated with gaba, gaba receptor, glutamate receptor, somatostatin, neuropeptide and serotonin
4) Confidence 0.32 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.36 Pain Relevance 0.38

General Comments

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