INT197210

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 3.15
Pain Relevance 16.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik1) plasma membrane (Grik1)
Anatomy Link Frequency
neurons 7
pyramidal neurons 4
amygdala 4
spinal cord 2
spinal 1
Grik1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 626 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
Neuropeptide 4 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
substantia gelatinosa 627 99.88 Very High Very High Very High
Pyramidal cell 350 99.84 Very High Very High Very High
amygdala 1691 99.68 Very High Very High Very High
Glutamate receptor 30 99.68 Very High Very High Very High
GABA receptor 2 99.60 Very High Very High Very High
Glutamate 75 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 711 99.36 Very High Very High Very High
Nociception 79 97.68 Very High Very High Very High
Pain 49 79.08 Quite High
Targeted Disruption 164 75.28 Quite High
Neurodegenerative Disease 12 75.12 Quite High
INFLAMMATION 11 71.44 Quite High
Adhesions 2 67.36 Quite High
Epilepsy 11 59.72 Quite High
Inflammatory Pain 11 58.64 Quite High
Ganglion Cysts 154 53.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have shown that endogenous activation of presynaptic GluR5 KARs in interneurons modulate the inhibitory transmission in hippocampus, basolateral amygdala and spinal cord [25,41,44].
Positive_regulation (activation) of GluR5 in amygdala associated with hippocampus, amygdala and spinal cord
1) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.87
Tonic activation of GluR5 KARs modulate inhibitory synaptic transmission in SG neurons
Positive_regulation (activation) of GluR5 in neurons associated with substantia gelatinosa
2) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.81
Consistently, we found that ATPA markedly increased the frequency of sIPSCs in all SG neurons tested in the presence of bicuculline or strychnine, suggesting that the activation of GluR5 facilitates both GABAergic and glycinergic transmission in the SG.


Positive_regulation (activation) of GluR5 in neurons associated with substantia gelatinosa and gabaergic
3) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.83
Therefore, we wanted to know whether tonic activation of presynaptic GluR5 KARs modulates inhibitory synaptic transmission in SG neurons in the spinal cord.
Spec (whether) Positive_regulation (activation) of GluR5 in spinal cord associated with substantia gelatinosa and spinal cord
4) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.78
The result suggests the tonic activation of GluR5 in the spinal SG.
Positive_regulation (activation) of GluR5 in spinal associated with substantia gelatinosa
5) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.07 Pain Relevance 0.64
Both GABAergic and glycinergic release were enhanced by GluR5 activation in SG neurons
Positive_regulation (activation) of GluR5 in neurons associated with substantia gelatinosa and gabaergic
6) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.67
To investigate whether presynaptic GluR5 KARs are activated by endogenous glutamate, we examined the effect of bath application of GluR5 antagonist, LY293558, on sIPSCs in spinal SG neurons.
Spec (whether) Positive_regulation (activated) of GluR5 in neurons associated with substantia gelatinosa, glutamate and antagonist
7) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.63
As ATPA induced firing of interneurons, we speculated that activation of GluR5 would affect GABA release in the BLA.
Positive_regulation (activation) of GluR5 in interneurons associated with gaba and amygdala
8) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.66
Activation of GluR5 Enhances Spontaneous GABAergic, but not Glutamatergic Neurotransmission, in the Basolateral Amygdala
Positive_regulation (Activation) of GluR5 in Amygdala associated with gabaergic and amygdala
9) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.70
Therefore, we believe that GluR5 is tonically activated by endogenous glutamate in the extracellular fluid.
Positive_regulation (activated) of GluR5 associated with glutamate
10) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.32
Therefore, activation of GluR5 reduces the excitability of pyramidal cells in the BLA.
Positive_regulation (activation) of GluR5 in pyramidal cells associated with pyramidal cell and amygdala
11) Confidence 0.55 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.61
Next, we measured the effect of GluR5 activation on evoked EPSCs (eEPSCs) in CeM neurons obtained by stimulating the BLA.
Positive_regulation (activation) of GluR5 in neurons associated with amygdala
12) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.90
These findings indicate that the activation of GluR5 in the BLA exerts an inhibitory effect on excitatory output to the CeM in the amygdala.


Positive_regulation (activation) of GluR5 in amygdala associated with amygdala
13) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.94
Among mediators of neurotransmission, multiple glutamate receptors (Gria3, Gria4, Grik1), a GABA transporter (Slc6a1), a serotonin receptor (Htr3a) and the neuropeptide somatostatin are increased, while a GABA receptor (Gabra2) and neuropeptides with specific sensory roles (Galanin, Adcyap1/PACAP) are decreased.
Positive_regulation (increased) of Grik1 associated with gaba, gaba receptor, glutamate receptor, somatostatin, neuropeptide and serotonin
14) Confidence 0.45 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.36 Pain Relevance 0.38
Activation of presynaptic GluR5 increases the frequency of mIPSCs in SG neurons
Positive_regulation (Activation) of GluR5 in neurons associated with substantia gelatinosa
15) Confidence 0.44 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.29
We found that the activation of GluR5 by ATPA increased the frequency of sIPSCs in all SG neurons tested.
Positive_regulation (activation) of GluR5 in neurons associated with substantia gelatinosa
16) Confidence 0.44 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.37
Since the deletion of GluR5 resulted in an increase in anxious behavior, we next wanted to determine if activation of GluR5 would have the opposite effect on anxiety.
Positive_regulation (activation) of GluR5 associated with anxiety disorder
17) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0.41 Pain Relevance 0.09
Furthermore, the current density of GluR5 activation was larger in interneurons as compared to pyramidal neurons.
Positive_regulation (activation) of GluR5 in pyramidal neurons associated with pyramidal cell
18) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0.25 Pain Relevance 0.47
mice, suggesting that endogenous activation of GluR5 in the BLA may modulate the functional output to the CeM.
Positive_regulation (activation) of GluR5 associated with amygdala
19) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0.05 Pain Relevance 0.78
Two lines of evidence in the present study directly showed that GluR5 is endogenously activated.
Positive_regulation (activated) of GluR5
20) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.36

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