INT197211

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Kars) translation (Kars) ligase activity (Kars)
cytoplasm (Kars)
Anatomy Link Frequency
neuronal 1
substantia gelatinosa 1
Kars (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 5 99.40 Very High Very High Very High
substantia gelatinosa 57 97.60 Very High Very High Very High
GABAergic 13 96.60 Very High Very High Very High
Glutamate 18 94.64 High High
agonist 8 79.92 Quite High
Glutamate receptor 4 78.08 Quite High
Central nervous system 16 73.28 Quite High
Multiple sclerosis 4 56.88 Quite High
nMDA receptor 6 37.20 Quite Low
Action potential 5 34.88 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 6 94.80 High High
Neurodegenerative Disease 27 93.32 High High
Nociception 7 92.52 High High
Necrosis 2 92.40 High High
Helminth Infection 1 91.04 High High
Death 27 69.12 Quite High
Convulsion 18 61.20 Quite High
Multiple Sclerosis 7 56.88 Quite High
Motor Neuron Diseases 1 55.52 Quite High
Disease 8 53.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the role of GluR5-containing KARs in the modulation of inhibitory transmission in the spinal substantia gelatinosa (SG) in slices remains unknown.
KARs Binding (role) of in substantia gelatinosa associated with substantia gelatinosa
1) Confidence 0.29 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1570342 Disease Relevance 0.09 Pain Relevance 0.34
Upon binding to KARs, KA induces a number of cellular events, including the influx of cellular Ca2+, production of reactive oxygen species (ROS), and mitochondrial dysfunction leading to neuronal apoptosis and necrosis [2].
KARs Binding (binding) of in neuronal associated with parkinson's disease, necrosis and neurodegenerative disease
2) Confidence 0.24 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 1.21 Pain Relevance 0.43

General Comments

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