INT197216

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Context Info
Confidence 0.80
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 16
Disease Relevance 0.39
Pain Relevance 6.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik1) plasma membrane (Grik1)
Anatomy Link Frequency
neurons 4
nociceptor 2
pyramidal neurons 1
Amygdala 1
Grik1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 165 100.00 Very High Very High Very High
amygdala 365 99.88 Very High Very High Very High
GABAergic 116 99.44 Very High Very High Very High
nociceptor 144 98.54 Very High Very High Very High
Dorsal horn 63 98.36 Very High Very High Very High
Dorsal horn neuron 25 97.64 Very High Very High Very High
substantia gelatinosa 285 97.36 Very High Very High Very High
Pyramidal cell 75 96.96 Very High Very High Very High
Pain 45 94.08 High High
Calcium channel 5 93.92 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 46 98.84 Very High Very High Very High
Pain 58 94.08 High High
Anxiety Disorder 155 50.00 Quite Low
INFLAMMATION 13 23.76 Low Low
Nociception 99 23.64 Low Low
Ganglion Cysts 19 6.48 Low Low
Hypersensitivity 16 5.00 Very Low Very Low Very Low
Decapitation 8 5.00 Very Low Very Low Very Low
Injury 8 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another recent report showed a low level of co-localization between GluR5 and GAD65-immunopositive terminals in the adult rat [32].
Localization (localization) of GluR5
1) Confidence 0.80 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.37
Therefore, the co-localization of GABA and GluR5 may also reflect, to some extent, the co-localization of glycine and GluR5.
Localization (localization) of GluR5 associated with gaba
2) Confidence 0.80 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.80
As the activation of GluR5 facilitated presynaptic GABA/Glycine release, it is conceivable that the knockout of GluR5 may affect inhibitory synaptic transmission.
Localization (release) of GluR5 associated with targeted disruption and gaba
3) Confidence 0.75 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.10 Pain Relevance 0.22
At P0, Grik1/GluR5 was largely co-localized with c-ret (data not shown).
Localization (localized) of GluR5
4) Confidence 0.70 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.05 Pain Relevance 0.26
Several studies have indirectly pointed to a localization of Grik1/GluR5 in the isolectin B4 binding DRG neuron sub-population.
Localization (localization) of GluR5 in neuron
5) Confidence 0.70 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.09 Pain Relevance 0.22
Several studies have indirectly pointed to a localization of Grik1/GluR5 in the isolectin B4 binding DRG neuron sub-population.
Localization (localization) of Grik1 in neuron
6) Confidence 0.70 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.09 Pain Relevance 0.22
Therefore, the co-localization of GABA and GluR5 may also reflect, to some extent, the co-localization of glycine and GluR5.
Localization (localization) of GluR5 associated with gaba
7) Confidence 0.70 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.77
Taken together, these results lead us to conclude that: (1) GluR5 is predominant and highly functional in interneurons; activation of GluR5 in this cell type triggers neuronal firing and subsequent release of GABA; (2) Significantly less GluR5 activity (or expression) is found in pyramidal neurons as compared to levels in interneurons; (3) GluR5 activation in pyramidal neurons may be counteracted by the activation of GABAA receptors, resulting from the bulk release of GABA from interneurons which were fired by GluR5 activation.
Localization (release) of GluR5 in pyramidal neurons associated with gaba and pyramidal cell
8) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.61
These cells correspond to the isolectin B4 positive nociceptor population as shown by double labelling where there was 87 % +/- 0.3 co-localisation of Grik1/GluR5 and isolectin B4 (Figure 4O).
Localization (localisation) of Grik1 in nociceptor associated with nociceptor
9) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.22
These cells correspond to the isolectin B4 positive nociceptor population as shown by double labelling where there was 87 % +/- 0.3 co-localisation of Grik1/GluR5 and isolectin B4 (Figure 4O).
Localization (localisation) of GluR5 in nociceptor associated with nociceptor
10) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.22
In the adult, Grik1/GluR5 never co-localized with TrkA and was restricted to small cell-diameter c-Ret+/isolectin B4+ neurons.
Localization (localized) of Grik1 in neurons
11) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.22
In the adult, Grik1/GluR5 never co-localized with TrkA and was restricted to small cell-diameter c-Ret+/isolectin B4+ neurons.
Localization (localized) of GluR5 in neurons
12) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.22
Modulation of both GABAergic and glycinergic inhibitory transmission by GluR5
Localization (transmission) of GluR5 associated with gabaergic
13) Confidence 0.65 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.69
At P0, Grik1/GluR5 was largely co-localized with c-ret (data not shown).
Localization (localized) of Grik1
14) Confidence 0.62 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.05 Pain Relevance 0.26
Role of GluR5 in Excitatory Synaptic Transmission and Plasticity from the Basolateral Amygdala to Central Amygdala
Localization (Role) of GluR5 in Amygdala associated with amygdala
15) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.89
Genetic deletion of GluR5 or pharmacological blockade of GluR5 could significantly reduce the tonic GABA current.
Localization (deletion) of GluR5 associated with gaba
16) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.59

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