INT197219

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 0.83
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik1) plasma membrane (Grik1)
Anatomy Link Frequency
spinal cord 5
neurons 4
amygdala 3
Grik1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 99.90 Very High Very High Very High
substantia gelatinosa 342 99.88 Very High Very High Very High
Glutamate 18 99.40 Very High Very High Very High
antagonist 48 98.90 Very High Very High Very High
intrathecal 6 98.06 Very High Very High Very High
Spinal cord 114 97.76 Very High Very High Very High
Hippocampus 12 97.52 Very High Very High Very High
amygdala 6 97.12 Very High Very High Very High
Dorsal horn 68 96.68 Very High Very High Very High
Analgesic 6 94.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.90 Very High Very High Very High
Nociception 58 99.30 Very High Very High Very High
Inflammatory Pain 6 90.96 High High
Pain 28 76.80 Quite High
Anxiety Disorder 6 43.76 Quite Low
Epilepsy 6 43.52 Quite Low
Targeted Disruption 26 38.88 Quite Low
Overdose 6 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, intrathecal injection of a selective GluR5 antagonist reduced nociceptive responses to CFA inflammation and GluR5 expression was increased in the spinal cords of CFA treated animals [50].
Positive_regulation (increased) of Gene_expression (expression) of GluR5 in spinal cords associated with nociception, inflammation, antagonist and intrathecal
1) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.72 Pain Relevance 0.73
Previous studies have shown that endogenous activation of presynaptic GluR5 KARs in interneurons modulate the inhibitory transmission in hippocampus, basolateral amygdala and spinal cord [25,41,44].
Positive_regulation (activation) of Gene_expression (presynaptic) of GluR5 in amygdala associated with hippocampus, amygdala and spinal cord
2) Confidence 0.50 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.87
Therefore, we wanted to know whether tonic activation of presynaptic GluR5 KARs modulates inhibitory synaptic transmission in SG neurons in the spinal cord.
Spec (whether) Positive_regulation (activation) of Gene_expression (presynaptic) of GluR5 in spinal cord associated with substantia gelatinosa and spinal cord
3) Confidence 0.50 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.78
To investigate whether presynaptic GluR5 KARs are activated by endogenous glutamate, we examined the effect of bath application of GluR5 antagonist, LY293558, on sIPSCs in spinal SG neurons.
Spec (whether) Positive_regulation (activated) of Spec (whether) Gene_expression (presynaptic) of GluR5 in neurons associated with substantia gelatinosa, glutamate and antagonist
4) Confidence 0.50 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.63
Nevertheless, our in situ hybridization and QRT-PCR results suggest that high Grik1/GluR5 expression appears at the late embryonic phase.
Positive_regulation (high) of Gene_expression (expression) of Grik1
5) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.05 Pain Relevance 0.25
Nevertheless, our in situ hybridization and QRT-PCR results suggest that high Grik1/GluR5 expression appears at the late embryonic phase.
Positive_regulation (high) of Gene_expression (expression) of GluR5
6) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.05 Pain Relevance 0.25
Activation of presynaptic GluR5 increases the frequency of mIPSCs in SG neurons
Positive_regulation (Activation) of Gene_expression (presynaptic) of GluR5 in neurons associated with substantia gelatinosa
7) Confidence 0.44 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.29
Previous studies have shown that endogenous activation of presynaptic GluR5 KARs in interneurons modulate the inhibitory transmission in hippocampus, basolateral amygdala and spinal cord [25,41,44].
Positive_regulation (activation) of in spinal cord Gene_expression (presynaptic) of GluR5 in amygdala associated with hippocampus, amygdala and spinal cord
8) Confidence 0.17 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.87

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