INT197220

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2006
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.29
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Kars) translation (Kars) ligase activity (Kars)
cytoplasm (Kars)
Anatomy Link Frequency
spinal cord 3
amygdala 3
neurons 2
Kars (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 12 99.40 Very High Very High Very High
substantia gelatinosa 228 98.68 Very High Very High Very High
Spinal cord 72 97.76 Very High Very High Very High
Hippocampus 8 97.72 Very High Very High Very High
amygdala 4 97.12 Very High Very High Very High
antagonist 32 96.88 Very High Very High Very High
Dorsal horn 44 96.68 Very High Very High Very High
GABAergic 52 93.08 High High
gABA 48 81.08 Quite High
Dorsal horn neuron 20 68.64 Quite High
Disease Link Frequency Relevance Heat
Fracture Healing 64 95.84 Very High Very High Very High
Osteoporosis 3 82.60 Quite High
Targeted Disruption 16 39.28 Quite Low
Epilepsy 4 21.20 Low Low
Anxiety Disorder 4 20.40 Low Low
Pain 12 19.12 Low Low
Nociception 28 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we wanted to know whether tonic activation of presynaptic GluR5 KARs modulates inhibitory synaptic transmission in SG neurons in the spinal cord.
Spec (whether) Positive_regulation (activation) of Gene_expression (presynaptic) of KARs in spinal cord associated with substantia gelatinosa and spinal cord
1) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.78
Previous studies have shown that endogenous activation of presynaptic GluR5 KARs in interneurons modulate the inhibitory transmission in hippocampus, basolateral amygdala and spinal cord [25,41,44].
Positive_regulation (activation) of Gene_expression (presynaptic) of KARs in amygdala associated with hippocampus, amygdala and spinal cord
2) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.87
To investigate whether presynaptic GluR5 KARs are activated by endogenous glutamate, we examined the effect of bath application of GluR5 antagonist, LY293558, on sIPSCs in spinal SG neurons.
Spec (whether) Positive_regulation (activated) of Spec (whether) Gene_expression (presynaptic) of KARs in neurons associated with substantia gelatinosa, glutamate and antagonist
3) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.63
Previous studies have shown that endogenous activation of presynaptic GluR5 KARs in interneurons modulate the inhibitory transmission in hippocampus, basolateral amygdala and spinal cord [25,41,44].
Positive_regulation (activation) of in spinal cord Gene_expression (presynaptic) of KARs in amygdala associated with hippocampus, amygdala and spinal cord
4) Confidence 0.13 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.87
Given the important role of lysine crosslinks in the biosynthesis of collagen, it is interesting that lysyl-tRNA synthetase was the only tRNA synthetase gene that was overexpressed in our data.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of lysyl-tRNA synthetase
5) Confidence 0.04 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.29 Pain Relevance 0

General Comments

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