INT197221

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.69
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Kars) translation (Kars) ligase activity (Kars)
cytoplasm (Kars)
Anatomy Link Frequency
neurons 1
Kars (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 9 98.88 Very High Very High Very High
substantia gelatinosa 57 97.60 Very High Very High Very High
Pain 2 95.76 Very High Very High Very High
Migraine 2 95.56 Very High Very High Very High
Neuropathic pain 1 93.44 High High
gABA 14 91.12 High High
spinal dorsal horn 5 89.20 High High
GABAergic 13 83.28 Quite High
Spinal cord 18 81.20 Quite High
Action potential 5 63.36 Quite High
Disease Link Frequency Relevance Heat
Pain 4 95.76 Very High Very High Very High
Migraine Disorders 2 95.56 Very High Very High Very High
Status Epilepticus 4 95.28 Very High Very High Very High
Neuropathic Pain 1 93.44 High High
Death 27 76.72 Quite High
Brain Injury 4 73.52 Quite High
Targeted Disruption 8 50.80 Quite High
Neurodegenerative Disease 27 50.00 Quite Low
Toxicity 1 49.12 Quite Low
INFLAMMATION 16 32.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicated that genetic deletion of GluR5 KARs might have no effect on the basal synaptic transmission in SG neurons.


Negative_regulation (deletion) of KARs in neurons associated with substantia gelatinosa
1) Confidence 0.33 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.05 Pain Relevance 0.44
This suppressive effect is probably attributable to the inhibition of KARs.
Negative_regulation (inhibition) of KARs
2) Confidence 0.29 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 0.64 Pain Relevance 0.43

General Comments

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