INT197228

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rora) DNA binding (Rora)
Anatomy Link Frequency
neurons 10
Rora (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 285 100.00 Very High Very High Very High
GABAergic 65 99.52 Very High Very High Very High
gABA 60 94.84 High High
Spinal cord 90 93.92 High High
Glutamate 15 93.84 High High
Dorsal horn 55 92.40 High High
antagonist 40 85.80 High High
Dorsal horn neuron 25 82.40 Quite High
Calcium channel 5 78.68 Quite High
Neurotransmitter 5 73.44 Quite High
Disease Link Frequency Relevance Heat
Nociception 35 5.00 Very Low Very Low Very Low
Targeted Disruption 20 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low
Epilepsy 5 5.00 Very Low Very Low Very Low
Overdose 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 5 5.00 Very Low Very Low Very Low
Inflammatory Pain 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both GABAergic and glycinergic release were enhanced by GluR5 activation in SG neurons
Positive_regulation (activation) of Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa and gabaergic
1) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.70
M), inward currents could be observed in all SG neurons recorded during the application of ATPA (3 ?
Positive_regulation (observed) of Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
2) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.31
Consistently, we found that ATPA markedly increased the frequency of sIPSCs in all SG neurons tested in the presence of bicuculline or strychnine, suggesting that the activation of GluR5 facilitates both GABAergic and glycinergic transmission in the SG.


Positive_regulation (increased) of Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa and gabaergic
3) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.84
Activation of presynaptic GluR5 increases the frequency of mIPSCs in SG neurons
Positive_regulation (increases) of Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
4) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.29
M), inward currents could be observed in all SG neurons recorded during the application of ATPA (3 ?
Positive_regulation (during) of Gene_expression (neurons) of SG in neurons associated with substantia gelatinosa
5) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.31

General Comments

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