INT197229

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2006
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 1.89
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Kars) translation (Kars) ligase activity (Kars)
cytoplasm (Kars)
Anatomy Link Frequency
neurons 3
spinal cord 2
amygdala 1
interneurons 1
Kars (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 342 99.64 Very High Very High Very High
Glutamate 63 99.40 Very High Very High Very High
GABAergic 78 98.08 Very High Very High Very High
Action potential 30 98.00 Very High Very High Very High
Spinal cord 108 97.76 Very High Very High Very High
Hippocampus 42 97.72 Very High Very High Very High
amygdala 6 97.12 Very High Very High Very High
antagonist 51 96.88 Very High Very High Very High
Dorsal horn 66 95.96 Very High Very High Very High
cerebral cortex 3 90.04 High High
Disease Link Frequency Relevance Heat
Stress 30 93.80 High High
Death 81 90.08 High High
Convulsion 54 84.96 Quite High
Neurodegenerative Disease 81 81.72 Quite High
Recurrence 3 73.84 Quite High
Sprains And Strains 18 72.72 Quite High
Drug Induced Neurotoxicity 6 68.48 Quite High
Depression 3 66.44 Quite High
Anxiety Disorder 9 65.64 Quite High
Status Epilepticus 12 53.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tonic activation of GluR5 KARs modulate inhibitory synaptic transmission in SG neurons
Positive_regulation (activation) of KARs in neurons associated with substantia gelatinosa
1) Confidence 0.54 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.81
However, the enhancement of sIPSC frequency by kainate or ATPA was reported in most studies, suggesting that activation of KARs could fire interneurons and thereby facilitating action potential-dependent inhibitory transmission [2,40,41].
Positive_regulation (activation) of KARs in interneurons associated with action potential
2) Confidence 0.54 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.46
Therefore, we wanted to know whether tonic activation of presynaptic GluR5 KARs modulates inhibitory synaptic transmission in SG neurons in the spinal cord.
Spec (whether) Positive_regulation (activation) of KARs in spinal cord associated with substantia gelatinosa and spinal cord
3) Confidence 0.54 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.78
To investigate whether presynaptic GluR5 KARs are activated by endogenous glutamate, we examined the effect of bath application of GluR5 antagonist, LY293558, on sIPSCs in spinal SG neurons.
Spec (whether) Positive_regulation (activated) of KARs in neurons associated with substantia gelatinosa, glutamate and antagonist
4) Confidence 0.54 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.63
Previous studies have shown that endogenous activation of presynaptic GluR5 KARs in interneurons modulate the inhibitory transmission in hippocampus, basolateral amygdala and spinal cord [25,41,44].
Positive_regulation (activation) of KARs in amygdala associated with hippocampus, amygdala and spinal cord
5) Confidence 0.54 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.87
KARs are most abundant in CA3 region and the activation of KARs can induce the production of ROS and compromise the function of mitochondria in the region [14, 15].
Positive_regulation (activation) of KARs
6) Confidence 0.35 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 0.63 Pain Relevance 0.15
However, stimulation of KARs induces NO release, which, in turn, modulates glutamate transmission [53].
Positive_regulation (stimulation) of KARs associated with glutamate
7) Confidence 0.35 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 0.70 Pain Relevance 0.09
The stimulation of KARs excites CA3 neurons directly and increases glutamate efflux [16, 17].
Positive_regulation (stimulation) of KARs in neurons associated with glutamate
8) Confidence 0.23 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 0.56 Pain Relevance 0.15
Previous studies have shown that endogenous activation of presynaptic GluR5 KARs in interneurons modulate the inhibitory transmission in hippocampus, basolateral amygdala and spinal cord [25,41,44].
Positive_regulation (activation) of KARs in spinal cord associated with hippocampus, amygdala and spinal cord
9) Confidence 0.18 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.87

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox