INT197230

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik1) plasma membrane (Grik1)
Anatomy Link Frequency
amygdala 5
neurons 4
spinal cord 1
Grik1 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 243 100.00 Very High Very High Very High
substantia gelatinosa 171 99.64 Very High Very High Very High
Hippocampus 10 98.72 Very High Very High Very High
GABAergic 73 98.08 Very High Very High Very High
Spinal cord 56 97.20 Very High Very High Very High
gABA 106 86.08 High High
Dorsal horn 33 83.64 Quite High
antagonist 48 75.44 Quite High
Dorsal horn neuron 15 73.64 Quite High
Neuronal excitability 10 72.00 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 103 50.00 Quite Low
Targeted Disruption 24 50.00 Quite Low
Epilepsy 3 7.36 Low Low
Pain 11 5.28 Low Low
Nociception 21 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 5 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Inflammatory Pain 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have shown that endogenous activation of presynaptic GluR5 KARs in interneurons modulate the inhibitory transmission in hippocampus, basolateral amygdala and spinal cord [25,41,44].
Regulation (modulate) of Positive_regulation (activation) of GluR5 in amygdala associated with hippocampus, amygdala and spinal cord
1) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.87
Tonic activation of GluR5 KARs modulate inhibitory synaptic transmission in SG neurons
Regulation (modulate) of Positive_regulation (activation) of GluR5 in neurons associated with substantia gelatinosa
2) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.81
These findings indicate that the activation of GluR5 in the BLA exerts an inhibitory effect on excitatory output to the CeM in the amygdala.


Regulation (effect) of Positive_regulation (activation) of GluR5 in amygdala associated with amygdala
3) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.95
Next, we measured the effect of GluR5 activation on evoked EPSCs (eEPSCs) in CeM neurons obtained by stimulating the BLA.
Regulation (effect) of Positive_regulation (activation) of GluR5 in neurons associated with amygdala
4) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.90
Previous studies have shown that endogenous activation of presynaptic GluR5 KARs in interneurons modulate the inhibitory transmission in hippocampus, basolateral amygdala and spinal cord [25,41,44].
Regulation (modulate) of in spinal cord Positive_regulation (activation) of GluR5 in amygdala associated with hippocampus, amygdala and spinal cord
5) Confidence 0.15 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.87

General Comments

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