INT197250

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.83
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
goblet cells 2
ovary 1
Muc5ac (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 97 87.20 High High
fibrosis 14 79.36 Quite High
Inflammatory mediators 3 33.88 Quite Low
ketamine 1 27.40 Quite Low
anesthesia 1 26.20 Quite Low
Inflammatory response 5 23.32 Low Low
Pain 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 34 99.72 Very High Very High Very High
Dermoids 3 99.36 Very High Very High Very High
Respiratory Disease 6 99.12 Very High Very High Very High
Cyst 33 98.80 Very High Very High Very High
Teratoma 45 95.84 Very High Very High Very High
Airway Obstruction 7 92.80 High High
Hypersensitivity 28 92.24 High High
Cancer 36 90.72 High High
Carcinoma 6 89.40 High High
INFLAMMATION 99 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For determination of MUC1, MUC4, MUC5AC, and JNK protein expression, Western blot analysis was performed with MUC1 (Abcam, Cambridge, UK), MUC 4 (Invitrogen, Carlsbad, California), MUC 5AC antibody and JNK antibodies (Santa Cruz Biotechnology, Santa Cruz, CA, and Cell Signaling Technology, Beverly, MA).
Localization (determination) of MUC5AC
1) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.07 Pain Relevance 0
In summary, cysts in a mature cystic teratoma of the ovary had a viscous gel secretion containing MUC2, MUC5AC and MUC5B with considerably more polymer to degraded subunit which was resistant to reduction of disulphide bonds with DTT and completely digestible with papain.
Localization (secretion) of MUC5AC in ovary associated with dermoids and cyst
2) Confidence 0.67 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 1.51 Pain Relevance 0
The other one is made of the five, large secreted gel-forming mucins MUC6, MUC2, MUC5AC, MUC5B and MUC19, which are conserved between human and mouse [13-15] and form oligomeric structures [9,16,17].
Localization (secreted) of MUC5AC
3) Confidence 0.66 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.51 Pain Relevance 0.16
Muc5AC is the most common mucin secreted by goblet cells and it is the major gel-forming mucin in airway secretions.
Localization (secreted) of Muc5AC in goblet cells
4) Confidence 0.65 Published 2006 Journal Respir Res Section Body Doc Link PMC1570356 Disease Relevance 1.30 Pain Relevance 0.19
Thus far five secreted gel-forming mucins have been reported, four of which (MUC2, MUC5AC, MUC5B and MUC6) are coded for by a cluster of genes on chromosome 11p15 8.
Localization (four) of MUC5AC
5) Confidence 0.62 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.12 Pain Relevance 0
Western blotting confirmed the presence of MUC2, MUC5AC and MUC5B in the secreted gel.
Localization (presence) of MUC5AC
6) Confidence 0.62 Published 2007 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC1852400 Disease Relevance 0.51 Pain Relevance 0
Chitosan or thiolated chitosan did not reduce mucus hypersecretion; but less immunoreactive MUC5AC was observed in mice given theophylline treatment alone (Fig. 4A panelb), indicating that the drug was able to inhibit goblet cell mucus production.
Localization (hypersecretion) of MUC5AC in goblet cell
7) Confidence 0.57 Published 2006 Journal Respir Res Section Body Doc Link PMC1570356 Disease Relevance 0.81 Pain Relevance 0.21

General Comments

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