INT197252

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.93
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Muc1) nucleus (Muc1) cytoplasm (Muc1)
Anatomy Link Frequency
blood 1
pancreas 1
ovary 1
Muc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 96.36 Very High Very High Very High
imagery 96 82.32 Quite High
Inflammation 42 50.00 Quite Low
Inflammatory response 4 42.96 Quite Low
Pain 2 13.60 Low Low
isoflurane 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 6 99.84 Very High Very High Very High
Injury 4 98.44 Very High Very High Very High
Pancreatic Cancer 94 98.24 Very High Very High Very High
Colitis 2 97.04 Very High Very High Very High
Pancreatitis 10 96.36 Very High Very High Very High
Respiratory Disease 3 91.32 High High
Metastasis 2 89.16 High High
Cancer 84 87.40 High High
Cyst 22 83.52 Quite High
Ovarian Cysts 10 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, it was demonstrated that MUC1 is upregulated in blood of more than 90% of patients with pancreatic carcinoma [30].
Positive_regulation (upregulated) of MUC1 in blood associated with pancreatic cancer
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776527 Disease Relevance 0.93 Pain Relevance 0.04
MUC1 was the first reported membraneĀ–bound mucin, widely expressed by normal glandular epithelial cells and dramatically increased in malignant cells of the breast, ovary and pancreas 15.
Positive_regulation (increased) of MUC1 in pancreas associated with malignant neoplastic disease
2) Confidence 0.33 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.45 Pain Relevance 0
Therefore we suggest that ELISA measurements of serum HIP/HAP and MUC-1 levels could be added to a panel of tests for the routine screening of population to identify individuals at increased risk for the developing pancreatic carcinoma.
Positive_regulation (measurements) of MUC-1 associated with pancreatic cancer
3) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776527 Disease Relevance 1.03 Pain Relevance 0.21
MUC1 was the first reported membraneĀ–bound mucin, widely expressed by normal glandular epithelial cells and dramatically increased in malignant cells of the breast, ovary and pancreas 15.
Positive_regulation (increased) of MUC1 in ovary associated with malignant neoplastic disease
4) Confidence 0.11 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.45 Pain Relevance 0
In contrast, TCNs exhibited a more gradual increase in mucin I-S adsorption and greater binding at 12 h than unmodified chitosan (Fig. 1c).


Positive_regulation (increase) of mucin I-S
5) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1570356 Disease Relevance 0.06 Pain Relevance 0

General Comments

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