INT197286

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 18
Disease Relevance 9.78
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
epithelium 5
brain 2
neural 2
basal cells 1
Ahr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 63 99.36 Very High Very High Very High
midbrain 9 56.80 Quite High
Neurotransmitter 45 43.16 Quite Low
Analgesic 9 5.00 Very Low Very Low Very Low
ketamine 9 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 54 99.54 Very High Very High Very High
Neuroblastoma 81 99.50 Very High Very High Very High
Prostate Cancer 504 99.36 Very High Very High Very High
INFLAMMATION 63 99.36 Very High Very High Very High
Cancer 315 99.20 Very High Very High Very High
Malignant Neoplastic Disease 45 99.20 Very High Very High Very High
Repression 9 98.92 Very High Very High Very High
Stress 36 98.72 Very High Very High Very High
Drug Induced Neurotoxicity 63 96.68 Very High Very High Very High
Cytomegalovirus Infection 27 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the transfected AhR was expressed and functional in the N2a-R?
Positive_regulation (transfected) of Gene_expression (expressed) of AhR
1) Confidence 0.67 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
There have been several other examples in which transfected AhR has been found to be active in the host cells [56,57], although it remains unclear why ligand-dependent AhR is activated under conditions in the absence of either ligand or TCDD.
Positive_regulation (transfected) of Gene_expression (transfected) of AhR
2) Confidence 0.67 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.50 Pain Relevance 0.03
cells, which were stably transfected with AhR cDNA in an undifferentiated neuroblastoma cell line, Neuro2a.
Positive_regulation (transfected) of Gene_expression (transfected) of AhR associated with neuroblastoma
3) Confidence 0.48 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.32 Pain Relevance 0
The murine neuroblastoma cell line, Neuro2a, was transfected with AhR cDNA in the expression vector (pcDNA4/V5-His), which includes the V5 epitope and the cytomegalovirus promoter.
Positive_regulation (transfected) of Gene_expression (transfected) of AhR associated with neuroblastoma and cytomegalovirus infection
4) Confidence 0.48 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.29 Pain Relevance 0
Establishment of Neuro2a-AhR stable transfectant
Positive_regulation (transfectant) of Gene_expression (transfectant) of AhR
5) Confidence 0.48 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.26 Pain Relevance 0
Neruo2a cells transfected with AhR, named N2a-R?
Positive_regulation (transfected) of Gene_expression (transfected) of AhR
6) Confidence 0.48 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.29 Pain Relevance 0
Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells: neurotoxicology study

Background

Positive_regulation (Over) of Gene_expression (expression) of AhR in neural
7) Confidence 0.45 Published 2006 Journal Environ Health Section Title Doc Link PMC1570454 Disease Relevance 0.21 Pain Relevance 0
This is based on the finding that the increase of CYP1A1 mRNA expression caused by over-expression of exogenous AhR was clearly suppressed by repression of the AhR with siRNA.
Positive_regulation (over) of Gene_expression (expression) of AhR associated with repression
8) Confidence 0.45 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.49 Pain Relevance 0
Since the AhR has also been detected in various regions of the brain, the AhR may play a key role in the developmental neurotoxicity of dioxins.
Positive_regulation (detected) of Gene_expression (detected) of AhR in brain associated with drug induced neurotoxicity
9) Confidence 0.45 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.26 Pain Relevance 0
-TrCP depletion, we first infected LNCaP cells with inducible AhR shRNA.
Positive_regulation (inducible) of Gene_expression (depletion) of AhR
10) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.16 Pain Relevance 0
Chesire et al identified the AhR as a putative ?
Positive_regulation (putative) of Gene_expression (identified) of AhR
11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.67 Pain Relevance 0.04
Moreover, we noted that AhR expression is higher upon combining androgen ablation and ?
Positive_regulation (upon) of Gene_expression (expression) of AhR
12) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.78 Pain Relevance 0
AhR expression and activation is also significantly higher in tumor cells compared to benign glandular epithelium.


Positive_regulation (activation) of Gene_expression (expression) of AhR in epithelium associated with cancer
13) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816705 Disease Relevance 0.78 Pain Relevance 0
Interestingly, ligand administration did not affect cell growth even though it did upregulate expression of the classic AhR pathway target CYP1A1.
Positive_regulation (upregulate) of Gene_expression (expression) of AhR
14) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.68 Pain Relevance 0.05
We detected high AhR expression and activation in basal cells and atrophic epithelial cells of human cancer bearing prostates.
Positive_regulation (activation) of Gene_expression (expression) of AhR in epithelial cells associated with cancer
15) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816705 Disease Relevance 0.78 Pain Relevance 0
Moreover, we noted that AhR expression is higher upon combining androgen ablation and ?
Positive_regulation (higher) of Gene_expression (expression) of AhR
16) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.78 Pain Relevance 0
We conclude that different stress signals, including inflammation, atrophy and androgen ablation upregulate AhR expression in both normal and malignant prostate cells and conduct a protective mechanism.
Positive_regulation (upregulate) of Gene_expression (expression) of AhR associated with stress, malignant neoplastic disease, inflammation and frailty
17) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 1.44 Pain Relevance 0.12
We found that AhR is normally expressed at low levels in the prostatic epithelium basal cells (cytoplasmic and nuclear staining, Figure 6A) and is substantially upregulated in areas of proliferative inflammatory atrophy (PIA), considered a precursor lesion to cancer (Figure 6B).
Positive_regulation (upregulated) of in basal cells Gene_expression (expressed) of AhR in epithelium associated with inflammation, cancer and frailty
18) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 1.09 Pain Relevance 0.12

General Comments

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