INT1973

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Context Info
Confidence 0.65
First Reported 1978
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 36
Total Number 38
Disease Relevance 14.78
Pain Relevance 7.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (NAGLU) lysosome (NAGLU)
Anatomy Link Frequency
plasma 6
urine 6
spinal 1
neutrophil 1
NAGLU (Homo sapiens)
Pain Link Frequency Relevance Heat
Restless leg syndrome 120 99.28 Very High Very High Very High
anesthesia 42 99.08 Very High Very High Very High
epidural 6 98.64 Very High Very High Very High
cINOD 16 98.38 Very High Very High Very High
Angina 12 97.92 Very High Very High Very High
isoflurane 7 97.64 Very High Very High Very High
aspirin 33 97.56 Very High Very High Very High
Paracetamol 19 97.56 Very High Very High Very High
halothane 1 96.72 Very High Very High Very High
corticosteroid 3 94.80 High High
Disease Link Frequency Relevance Heat
Rheumatic Diseases 1 99.80 Very High Very High Very High
Cyst 2 99.66 Very High Very High Very High
Injury 73 99.60 Very High Very High Very High
Proteinuria 14 99.60 Very High Very High Very High
Heart Rate Under Development 9 99.60 Very High Very High Very High
Toxicity 17 99.48 Very High Very High Very High
Increased Venous Pressure Under Development 129 99.28 Very High Very High Very High
Disorders Of Creatine Metabolism 4 99.24 Very High Very High Very High
Myocardial Infarction 51 98.88 Very High Very High Very High
Acute Renal Failure 5 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The objective of the study was to investigate whether the lysosomal enzyme, N-Acetyl-beta-D-glucosaminidase (NAG) activity is increased in plasma of patients with acute myocardial infarction (AMI) and to determine if there is any association between plasma levels of NAG and severity of myocardial infarction (MI).
Spec (whether) Positive_regulation (increased) of N-Acetyl-beta-D-glucosaminidase in plasma associated with myocardial infarction
1) Confidence 0.65 Published 2003 Journal Exp. Mol. Med. Section Abstract Doc Link 14508067 Disease Relevance 0.67 Pain Relevance 0
The objective of the study was to investigate whether the lysosomal enzyme, N-Acetyl-beta-D-glucosaminidase (NAG) activity is increased in plasma of patients with acute myocardial infarction (AMI) and to determine if there is any association between plasma levels of NAG and severity of myocardial infarction (MI).
Spec (whether) Positive_regulation (increased) of NAG in plasma associated with myocardial infarction
2) Confidence 0.65 Published 2003 Journal Exp. Mol. Med. Section Abstract Doc Link 14508067 Disease Relevance 0.67 Pain Relevance 0
The activity of N-acetyl-beta-glucosaminidase (NAG) was found to be increased in serial plasma samples from patients with acute myocardial infarction (AMI).
Positive_regulation (increased) of N-acetyl-beta-glucosaminidase in plasma associated with myocardial infarction
3) Confidence 0.63 Published 1980 Journal Adv Myocardiol Section Abstract Doc Link 6999562 Disease Relevance 0.50 Pain Relevance 0.09
The activity of N-acetyl-beta-glucosaminidase (NAG) was found to be increased in serial plasma samples from patients with acute myocardial infarction (AMI).
Positive_regulation (increased) of NAG in plasma associated with myocardial infarction
4) Confidence 0.63 Published 1980 Journal Adv Myocardiol Section Abstract Doc Link 6999562 Disease Relevance 0.50 Pain Relevance 0.09
Cyclosporine induced a slight increase in AAP and NAG excretion.
Positive_regulation (increase) of NAG
5) Confidence 0.54 Published 1989 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 2571317 Disease Relevance 0.15 Pain Relevance 0.24
The activities of both N-acetyl-beta-glucosaminidase and beta-glucuronidase were elevated in plasma during the first 24 h after the onset of chest pain in patients with acute myocardial infarction and the peak levels of N-acetyl-beta-glucosaminidase correlated well with those of creatine kinase.
Positive_regulation (elevated) of N-acetyl-beta-glucosaminidase in plasma associated with angina and myocardial infarction
6) Confidence 0.42 Published 1978 Journal Cardiovasc. Res. Section Abstract Doc Link 647716 Disease Relevance 0.41 Pain Relevance 0.20
The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was elevated in four patients; two had other biochemical evidence of renal damage while the other two patients appeared normal, although they had both received spinal irradiation in the past.
Positive_regulation (elevated) of N-acetyl-beta-D-glucosaminidase in spinal
7) Confidence 0.41 Published 1987 Journal Br. J. Rheumatol. Section Abstract Doc Link 3664158 Disease Relevance 0.95 Pain Relevance 0.54
An elevated NAG level was particularly common in patients receiving gold or aspirin therapy.
Positive_regulation (elevated) of NAG associated with aspirin
8) Confidence 0.40 Published 1978 Journal Am. J. Med. Section Abstract Doc Link 311157 Disease Relevance 0.42 Pain Relevance 0.24
In addition, the increased urinary excretion of beta2-microglobulin (beta2MG) and N-acetyl-beta-D-glucosaminidase (NAG) on admission was also improved during the treatment.
Positive_regulation (increased) of NAG
9) Confidence 0.40 Published 2008 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 18274699 Disease Relevance 0.81 Pain Relevance 0.37
Short term therapies by NSAIDs were without influence on enzymuria but long term therapies produced a moderate increase of NAG excretion.
Positive_regulation (increase) of NAG associated with cinod
10) Confidence 0.36 Published 1989 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 2571317 Disease Relevance 0.16 Pain Relevance 0.26
The primary outcome measure was renal injury as measured by the increases in urinary N-acetyl-beta-d-glucosaminidase (NAG)/creatinine ratio (indicator of renal tubular injury) and urinary albumin/creatinine ratio (indicator of glomerular injury).
Positive_regulation (increases) of N-acetyl-beta-d-glucosaminidase associated with injury
11) Confidence 0.34 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717300 Disease Relevance 0.54 Pain Relevance 0.10
Neither auranofin nor myocrisin were found to further significantly increase beta 2M and NAG excretion.
Positive_regulation (increase) of NAG
12) Confidence 0.32 Published 1983 Journal Clin. Rheumatol. Section Abstract Doc Link 6432404 Disease Relevance 0.70 Pain Relevance 0.52
The increase in urinary NAG excretion was dose related with sevoflurane, but there was no difference in results of routine laboratory renal tests on days 2 and 3 after anesthesia among the three groups.
Positive_regulation (increase) of NAG
13) Confidence 0.32 Published 1995 Journal Anesthesiology Section Body Doc Link 7661345 Disease Relevance 0 Pain Relevance 0
However, the increase in urinary NAG excretion was not indicative of clinically significant renal damage in these patients with no preexisting renal disease.


Positive_regulation (increase) of NAG
14) Confidence 0.32 Published 1995 Journal Anesthesiology Section Body Doc Link 7661345 Disease Relevance 0 Pain Relevance 0
Increased lysosomal turnover, such as that caused by proteinuria results in a small increase in urinary NAG.
Positive_regulation (increase) of NAG associated with proteinuria
15) Confidence 0.27 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.58 Pain Relevance 0.27
KEY FINDINGS: BDL significantly increased NAG activity compared to sham groups.
Positive_regulation (increased) of NAG
16) Confidence 0.26 Published 2010 Journal Life Sci. Section Body Doc Link 20153756 Disease Relevance 0.15 Pain Relevance 0
To measure the urine tubular enzymes N-acetyl-beta-glucosaminidase (NAG), alpha 1-microglobulin (alpha 1-M), and beta 2-microglobulin (beta 2-M) for renal tubular injury in both groups.
Positive_regulation (measure) of N-acetyl-beta-glucosaminidase in urine associated with injury
17) Confidence 0.26 Published 1994 Journal J Clin Anesth Section Abstract Doc Link 7527229 Disease Relevance 0.10 Pain Relevance 0.65
To measure the urine tubular enzymes N-acetyl-beta-glucosaminidase (NAG), alpha 1-microglobulin (alpha 1-M), and beta 2-microglobulin (beta 2-M) for renal tubular injury in both groups.
Positive_regulation (measure) of NAG in urine associated with injury
18) Confidence 0.26 Published 1994 Journal J Clin Anesth Section Abstract Doc Link 7527229 Disease Relevance 0.10 Pain Relevance 0.65
The primary outcome measure was renal injury as measured by the increases in urinary N-acetyl-beta-d-glucosaminidase (NAG)/creatinine ratio (indicator of renal tubular injury) and urinary albumin/creatinine ratio (indicator of glomerular injury).
Positive_regulation (increases) of NAG associated with injury
19) Confidence 0.25 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717300 Disease Relevance 0.54 Pain Relevance 0.10
NAG was elevated in patients with intermittent claudication compared to volunteers at baseline suggesting on-going renal insult in patients with intermittent claudication.
Positive_regulation (elevated) of NAG associated with restless leg syndrome
20) Confidence 0.25 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.92 Pain Relevance 0.83

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