INT197322

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.52
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
cleavage 1
lateral ventricles 1
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 91.56 High High
cINOD 55 81.44 Quite High
cytokine 11 71.84 Quite High
cOX1 2 62.92 Quite High
nMDA receptor 10 59.40 Quite High
COX2 21 41.40 Quite Low
Potency 1 32.88 Quite Low
dexamethasone 46 26.80 Quite Low
corticosteroid 3 23.48 Low Low
long-term potentiation 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 37 100.00 Very High Very High Very High
Targeted Disruption 29 99.96 Very High Very High Very High
Disease 182 99.44 Very High Very High Very High
Disorder Of Lipid Metabolism 20 98.98 Very High Very High Very High
Disease Progression 13 96.92 Very High Very High Very High
Stress 29 96.64 Very High Very High Very High
INFLAMMATION 58 91.56 High High
Amnesia 1 91.36 High High
Cognitive Disorder 14 91.20 High High
Brain Disease 1 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurodegeneration in Apo E-/- mice exposed to concentrated ambient particulate matter: influence of oxidative stress
Protein_catabolism (Neurodegeneration) of Apo E associated with stress
1) Confidence 0.71 Published 2006 Journal Part Fibre Toxicol Section Body Doc Link PMC1570474 Disease Relevance 1.06 Pain Relevance 0.03
In the present study, we report the effect of prolonged enzymatic degradation of the endothelial surface layer in vivo during the early process of atherogenesis in apoE knockout (apoE?
Protein_catabolism (degradation) of apoE associated with targeted disruption and atherosclerosis
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999536 Disease Relevance 0.52 Pain Relevance 0
ESL degradation in apoE deficient mice contributes to reduced increased urinary protein excretion without significant changes in renal morphology.
Protein_catabolism (degradation) of apoE
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2999536 Disease Relevance 0.48 Pain Relevance 0.05
These critical questions will never be fully answered without a complete understanding of the life cycle of the apolipoprotein receptors that mediate the uptake, signaling, and degradation of apoE.
Protein_catabolism (degradation) of apoE associated with disorder of lipid metabolism
4) Confidence 0.64 Published 2006 Journal Mol Neurodegener Section Abstract Doc Link PMC1635701 Disease Relevance 0.59 Pain Relevance 0
In addition, cleavage of apoE receptors could be a necessary step in receptor turnover, affecting receptor half-lives, and in preventing uptake of apoE-containing lipoproteins.
Protein_catabolism (cleavage) of apoE in cleavage
5) Confidence 0.64 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.03
Most of the evidence indicates that ApoE promotes the clearance and/or degradation of A?
Protein_catabolism (degradation) of ApoE
6) Confidence 0.48 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2998033 Disease Relevance 0.55 Pain Relevance 0.41
In a previous study we demonstrated that murine MSCs (mMSCs) injected into the lateral ventricles of 4 day old ApoE null mice secreted small amounts of ApoE into the tissue [24].
Protein_catabolism (day) of ApoE in lateral ventricles
7) Confidence 0.21 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.32 Pain Relevance 0

General Comments

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