INT197359

Context Info Confidence 0.11 First Reported 2006 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.54 Pain Relevance 0.40

mitochondrion (MCAT)

Anatomy Link Frequency brain 2 epithelium 2 MCAT (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 52 97.76 tolerance 3 5.00 Dismenorea 2 5.00 Dopamine 2 5.00 Spinal cord 1 5.00 Inflammation 1 5.00 adenocard 1 5.00 Pain 1 5.00 analgesia 1 5.00 pain pelvic 1 5.00

Disease Link Frequency Relevance Heat Disease 110 99.48 Cicatrix 47 97.96 Endometriosis 90 97.76 Stroke 3 61.20 Apoptosis 11 5.00 Parkinson's Disease 5 5.00 Cancer 5 5.00 Death 4 5.00 Endometriosis (extended) 3 5.00 Cyst 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

No differences in MT expression in the glandular epithelium were observed between scar endometriosis and the control group (Table 5.)

Neg (No) Regulation (differences) of Gene_expression (expression) of MT in epithelium associated with endometriosis and cicatrix

1) Confidence 0.11 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.68 Pain Relevance 0.40

Previous studies suggest that mtETC subunit expression was also altered in sporadic PD brain. [30] Complex I subunits were also oxidatively damaged and this damage correlated with decreased function in sporadic PD brain. [30] Findings of reduced capacity of the electron transport chain, routine respiration and complex I mediated oxygen utilization (Figure 4) in PD cybrid neuronal cells, complimented our mtETC assembly data.

Regulation (altered) of Gene_expression (expression) of mtETC in brain associated with disease

2) Confidence 0.01 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2711937 Disease Relevance 0.86 Pain Relevance 0

General Comments

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