INT197364

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 24.11
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MCAT)
Anatomy Link Frequency
macrophages 3
epithelium 3
stroma 2
endometrium 2
gray matter 1
MCAT (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 780 99.72 Very High Very High Very High
Migraine 53 91.92 High High
depression 23 89.88 High High
tolerance 45 75.16 Quite High
hyperexcitability 6 62.80 Quite High
Pain 16 60.00 Quite High
imagery 19 59.28 Quite High
pain pelvic 15 44.36 Quite Low
Dismenorea 30 42.96 Quite Low
headache 8 25.00 Low Low
Disease Link Frequency Relevance Heat
Cicatrix 705 99.84 Very High Very High Very High
Endometriosis 1350 99.72 Very High Very High Very High
Death 53 99.72 Very High Very High Very High
Cancer 167 99.40 Very High Very High Very High
Apoptosis 199 99.12 Very High Very High Very High
Endometriosis (extended) 46 98.96 Very High Very High Very High
Disease 111 98.80 Very High Very High Very High
Carcinoma 16 97.80 Very High Very High Very High
Nasopharynx Cancer 4 96.14 Very High Very High Very High
Necrosis 22 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A higher level of MT expression has been demonstrated in the eutopic endometrium simultaneously with the increasing number and activity of cytotoxic cells [10].
Gene_expression (expression) of MT in endometrium
1) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.41 Pain Relevance 0.19
MT expression was also demonstrated in endometrial cancer and ovarian endometriosis [16].
Gene_expression (expression) of MT associated with endometriosis and endometriosis (extended)
2) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.40 Pain Relevance 0.15
The resistance to immune mediated apoptosis of the endometrial cells can be related to MT expression [38-41].
Gene_expression (expression) of MT associated with apoptosis
3) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.20 Pain Relevance 0.19
MT expression seems to protect endometrial cells against apoptosis enabling them to acquire resistance to immune-mediated apoptosis [10].
Gene_expression (expression) of MT associated with apoptosis
4) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.59 Pain Relevance 0.19
MT expression correlated in cancer tissue with reduced apoptosis in carcinoma cells [15].
Gene_expression (expression) of MT associated with cancer, carcinoma and apoptosis
5) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.21 Pain Relevance 0.09
In the present study MT expression in ovarian endometriosis was at the lowest level when compared to the eutopic endometrium and scar endometriosis.
Gene_expression (expression) of MT in endometrium associated with endometriosis and cicatrix
6) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.36 Pain Relevance 0.22
No differences in MT expression in the glandular epithelium were observed between scar endometriosis and the control group (Table 5.)
Gene_expression (expression) of MT in epithelium associated with endometriosis and cicatrix
7) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.67 Pain Relevance 0.40
However, no differences of MT expression in scar endometriosis between the glandular epithelium and the stroma were found.


Gene_expression (expression) of MT in epithelium associated with endometriosis and cicatrix
8) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.90 Pain Relevance 0.52
High MT expression in scar endometriomas was accompanied by the growing number of CD25- and CD69-positive immune cells, while low MT expression in ovarian endometriomas accompanied by a lower number of CD25- and CD69-positive immune cells coexisted with the presence of RCAS1-positive macrophages.
Gene_expression (expression) of MT in macrophages associated with endometriosis and cicatrix
9) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.30 Pain Relevance 0.18
The difference in MT expression between the ovarian glandular epithelium and ovarian stroma was observed and was statistically significant (p = 0.01).
Gene_expression (expression) of MT in stroma
10) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.75 Pain Relevance 0.46
High MT expression in scar endometriomas was accompanied by the growing number of CD25- and CD69-positive immune cells, while low MT expression in ovarian endometriomas accompanied by a lower number of CD25- and CD69-positive immune cells coexisted with the presence of RCAS1-positive macrophages.
Gene_expression (expression) of MT in macrophages associated with endometriosis and cicatrix
11) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.38 Pain Relevance 0.19
The researchers also found differences between the white matter (the part of the brain that transfers information between different regions of the gray matter) immediately below the V3A and MT+ areas in the migraineurs and the controls but again not between the two groups of migraineurs.


Gene_expression (areas) of MT in gray matter
12) Confidence 0.14 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1609120 Disease Relevance 0.95 Pain Relevance 0.66
Five-micrometer sections from each case were stained to visualize expression of RCAS1, MT and CD16-, CD25-, CD69-, CD56-positive cells (mainly lymphocytes) as well as CD68+ cells, or macrophages.
Gene_expression (expression) of MT in macrophages
13) Confidence 0.13 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 0.41 Pain Relevance 0.06
Analysis of MT immunoreactivity
Gene_expression (Analysis) of MT
14) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.87 Pain Relevance 0.40
Moreover, differences in MT expression between epithelial cells and stroma were identified, what seems to confirm the reports on differences between apoptosis levels in the glandular epithelium and stroma in ovarian endometrioid cyst [43,44].
Gene_expression (expression) of MT in epithelium associated with cyst and apoptosis
15) Confidence 0.11 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.27 Pain Relevance 0.18
In another in vitro study [121] in well-differentiated HK1 nasopharyngeal cancer cells a differential up-regulation of metallothionein in isoforms was observed: MT-1E and MT-2A isoform were up-regulated of six hours following PDT, with an approximately 50-fold rise in the expression level of MT-1E and a 15-fold increase of MT-2A.
Gene_expression (expression) of MT associated with cancer and nasopharynx cancer
16) Confidence 0.05 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.32 Pain Relevance 0
Moreover, differences in MT expression between epithelial cells and stroma were identified, what seems to confirm the reports on differences between apoptosis levels in the glandular epithelium and stroma in ovarian endometrioid cyst [43,44].
Gene_expression (expression) of MT in stroma associated with cyst and apoptosis
17) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.27 Pain Relevance 0.18
Previous studies suggest that mtETC subunit expression was also altered in sporadic PD brain. [30] Complex I subunits were also oxidatively damaged and this damage correlated with decreased function in sporadic PD brain. [30] Findings of reduced capacity of the electron transport chain, routine respiration and complex I mediated oxygen utilization (Figure 4) in PD cybrid neuronal cells, complimented our mtETC assembly data.
Gene_expression (expression) of mtETC in brain associated with disease
18) Confidence 0.01 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2711937 Disease Relevance 0.85 Pain Relevance 0

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