INT197364
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
A higher level of MT expression has been demonstrated in the eutopic endometrium simultaneously with the increasing number and activity of cytotoxic cells [10]. | |||||||||||||||
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MT expression was also demonstrated in endometrial cancer and ovarian endometriosis [16]. | |||||||||||||||
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The resistance to immune mediated apoptosis of the endometrial cells can be related to MT expression [38-41]. | |||||||||||||||
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MT expression seems to protect endometrial cells against apoptosis enabling them to acquire resistance to immune-mediated apoptosis [10]. | |||||||||||||||
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MT expression correlated in cancer tissue with reduced apoptosis in carcinoma cells [15]. | |||||||||||||||
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In the present study MT expression in ovarian endometriosis was at the lowest level when compared to the eutopic endometrium and scar endometriosis. | |||||||||||||||
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No differences in MT expression in the glandular epithelium were observed between scar endometriosis and the control group (Table 5.) | |||||||||||||||
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However, no differences of MT expression in scar endometriosis between the glandular epithelium and the stroma were found.
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High MT expression in scar endometriomas was accompanied by the growing number of CD25- and CD69-positive immune cells, while low MT expression in ovarian endometriomas accompanied by a lower number of CD25- and CD69-positive immune cells coexisted with the presence of RCAS1-positive macrophages. | |||||||||||||||
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The difference in MT expression between the ovarian glandular epithelium and ovarian stroma was observed and was statistically significant (p = 0.01). | |||||||||||||||
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High MT expression in scar endometriomas was accompanied by the growing number of CD25- and CD69-positive immune cells, while low MT expression in ovarian endometriomas accompanied by a lower number of CD25- and CD69-positive immune cells coexisted with the presence of RCAS1-positive macrophages. | |||||||||||||||
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The researchers also found differences between the white matter (the part of the brain that transfers information between different regions of the gray matter) immediately below the V3A and MT+ areas in the migraineurs and the controls but again not between the two groups of migraineurs.
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Five-micrometer sections from each case were stained to visualize expression of RCAS1, MT and CD16-, CD25-, CD69-, CD56-positive cells (mainly lymphocytes) as well as CD68+ cells, or macrophages. | |||||||||||||||
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Analysis of MT immunoreactivity | |||||||||||||||
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Moreover, differences in MT expression between epithelial cells and stroma were identified, what seems to confirm the reports on differences between apoptosis levels in the glandular epithelium and stroma in ovarian endometrioid cyst [43,44]. | |||||||||||||||
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In another in vitro study [121] in well-differentiated HK1 nasopharyngeal cancer cells a differential up-regulation of metallothionein in isoforms was observed: MT-1E and MT-2A isoform were up-regulated of six hours following PDT, with an approximately 50-fold rise in the expression level of MT-1E and a 15-fold increase of MT-2A. | |||||||||||||||
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Moreover, differences in MT expression between epithelial cells and stroma were identified, what seems to confirm the reports on differences between apoptosis levels in the glandular epithelium and stroma in ovarian endometrioid cyst [43,44]. | |||||||||||||||
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Previous studies suggest that mtETC subunit expression was also altered in sporadic PD brain. [30] Complex I subunits were also oxidatively damaged and this damage correlated with decreased function in sporadic PD brain. [30] Findings of reduced capacity of the electron transport chain, routine respiration and complex I mediated oxygen utilization (Figure 4) in PD cybrid neuronal cells, complimented our mtETC assembly data. | |||||||||||||||
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