INT197364

Context Info Confidence 0.16 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 18 Total Number 18 Disease Relevance 24.11 Pain Relevance 4.27

mitochondrion (MCAT)

Anatomy Link Frequency macrophages 3 epithelium 3 stroma 2 endometrium 2 gray matter 1 MCAT (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 780 99.72 Migraine 53 91.92 depression 23 89.88 tolerance 45 75.16 hyperexcitability 6 62.80 Pain 16 60.00 imagery 19 59.28 pain pelvic 15 44.36 Dismenorea 30 42.96 headache 8 25.00

Disease Link Frequency Relevance Heat Cicatrix 705 99.84 Endometriosis 1350 99.72 Death 53 99.72 Cancer 167 99.40 Apoptosis 199 99.12 Endometriosis (extended) 46 98.96 Disease 111 98.80 Carcinoma 16 97.80 Nasopharynx Cancer 4 96.14 Necrosis 22 93.36

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A higher level of MT expression has been demonstrated in the eutopic endometrium simultaneously with the increasing number and activity of cytotoxic cells [10].

Gene_expression (expression) of MT in endometrium

1) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.41 Pain Relevance 0.19

MT expression was also demonstrated in endometrial cancer and ovarian endometriosis [16].

Gene_expression (expression) of MT associated with endometriosis and endometriosis (extended)

2) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.40 Pain Relevance 0.15

The resistance to immune mediated apoptosis of the endometrial cells can be related to MT expression [38-41].

Gene_expression (expression) of MT associated with apoptosis

3) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.20 Pain Relevance 0.19

MT expression seems to protect endometrial cells against apoptosis enabling them to acquire resistance to immune-mediated apoptosis [10].

Gene_expression (expression) of MT associated with apoptosis

4) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.59 Pain Relevance 0.19

MT expression correlated in cancer tissue with reduced apoptosis in carcinoma cells [15].

Gene_expression (expression) of MT associated with cancer, carcinoma and apoptosis

5) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.21 Pain Relevance 0.09

In the present study MT expression in ovarian endometriosis was at the lowest level when compared to the eutopic endometrium and scar endometriosis.

Gene_expression (expression) of MT in endometrium associated with endometriosis and cicatrix

6) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.36 Pain Relevance 0.22

No differences in MT expression in the glandular epithelium were observed between scar endometriosis and the control group (Table 5.)

Gene_expression (expression) of MT in epithelium associated with endometriosis and cicatrix

7) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.67 Pain Relevance 0.40

However, no differences of MT expression in scar endometriosis between the glandular epithelium and the stroma were found.

Gene_expression (expression) of MT in epithelium associated with endometriosis and cicatrix

8) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.90 Pain Relevance 0.52

High MT expression in scar endometriomas was accompanied by the growing number of CD25- and CD69-positive immune cells, while low MT expression in ovarian endometriomas accompanied by a lower number of CD25- and CD69-positive immune cells coexisted with the presence of RCAS1-positive macrophages.

Gene_expression (expression) of MT in macrophages associated with endometriosis and cicatrix

9) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.30 Pain Relevance 0.18

The difference in MT expression between the ovarian glandular epithelium and ovarian stroma was observed and was statistically significant (p = 0.01).

Gene_expression (expression) of MT in stroma

10) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.75 Pain Relevance 0.46

High MT expression in scar endometriomas was accompanied by the growing number of CD25- and CD69-positive immune cells, while low MT expression in ovarian endometriomas accompanied by a lower number of CD25- and CD69-positive immune cells coexisted with the presence of RCAS1-positive macrophages.

Gene_expression (expression) of MT in macrophages associated with endometriosis and cicatrix

11) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.38 Pain Relevance 0.19

The researchers also found differences between the white matter (the part of the brain that transfers information between different regions of the gray matter) immediately below the V3A and MT+ areas in the migraineurs and the controls but again not between the two groups of migraineurs.

Gene_expression (areas) of MT in gray matter

12) Confidence 0.14 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1609120 Disease Relevance 0.95 Pain Relevance 0.66

Five-micrometer sections from each case were stained to visualize expression of RCAS1, MT and CD16-, CD25-, CD69-, CD56-positive cells (mainly lymphocytes) as well as CD68+ cells, or macrophages.

Gene_expression (expression) of MT in macrophages

13) Confidence 0.13 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 0.41 Pain Relevance 0.06

Analysis of MT immunoreactivity

Gene_expression (Analysis) of MT

14) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.87 Pain Relevance 0.40

Moreover, differences in MT expression between epithelial cells and stroma were identified, what seems to confirm the reports on differences between apoptosis levels in the glandular epithelium and stroma in ovarian endometrioid cyst [43,44].

Gene_expression (expression) of MT in epithelium associated with cyst and apoptosis

15) Confidence 0.11 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.27 Pain Relevance 0.18

In another in vitro study [121] in well-differentiated HK1 nasopharyngeal cancer cells a differential up-regulation of metallothionein in isoforms was observed: MT-1E and MT-2A isoform were up-regulated of six hours following PDT, with an approximately 50-fold rise in the expression level of MT-1E and a 15-fold increase of MT-2A.

Gene_expression (expression) of MT associated with cancer and nasopharynx cancer

16) Confidence 0.05 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.32 Pain Relevance 0

Moreover, differences in MT expression between epithelial cells and stroma were identified, what seems to confirm the reports on differences between apoptosis levels in the glandular epithelium and stroma in ovarian endometrioid cyst [43,44].

Gene_expression (expression) of MT in stroma associated with cyst and apoptosis

17) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.27 Pain Relevance 0.18

Previous studies suggest that mtETC subunit expression was also altered in sporadic PD brain. [30] Complex I subunits were also oxidatively damaged and this damage correlated with decreased function in sporadic PD brain. [30] Findings of reduced capacity of the electron transport chain, routine respiration and complex I mediated oxygen utilization (Figure 4) in PD cybrid neuronal cells, complimented our mtETC assembly data.

Gene_expression (expression) of mtETC in brain associated with disease

18) Confidence 0.01 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2711937 Disease Relevance 0.85 Pain Relevance 0

General Comments

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