INT197374

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.43
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 213 100.00 Very High Very High Very High
Spinal cord 28 96.00 Very High Very High Very High
nMDA receptor 25 85.60 High High
Glutamate receptor 4 81.56 Quite High
c fibre 28 78.72 Quite High
spinal dorsal horn 50 77.68 Quite High
Glutamate 4 76.44 Quite High
Thermal hyperalgesia 2 66.00 Quite High
Hippocampus 18 65.28 Quite High
tetrodotoxin 3 59.64 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 2 4 94.64 High High
Cognitive Disorder 40 78.72 Quite High
Nervous System Injury 1 69.36 Quite High
Neuropathic Pain 3 66.96 Quite High
Hyperalgesia 8 66.00 Quite High
Appetite Loss 15 50.00 Quite Low
Pain 7 40.32 Quite Low
Congenital Anomalies 4 36.32 Quite Low
Schizophrenia 21 5.00 Very Low Very Low Very Low
Sprains And Strains 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results here show that targeted mutation of EphB1 receptor can prevent development of LTP and the associated phosphorylation of CaMKII and ERK and CREB and expression of c-Fos in the mouse SC.
Protein_catabolism (development) of LTP associated with long-term potentiation and spinal cord
1) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.26 Pain Relevance 0.67
The degree of LTP was comparable with estimates in other reports that employed similar protocols in mouse hippocampal slices [19,70-74].
Protein_catabolism (degree) of LTP associated with long-term potentiation
2) Confidence 0.46 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0 Pain Relevance 0.51
GMP; by elevating cGMP levels, LTP is facilitated
Protein_catabolism (facilitated) of LTP associated with long-term potentiation
3) Confidence 0.10 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704618 Disease Relevance 0.17 Pain Relevance 0.37
to high-frequency stimulation and required for subsequent development of LTP) clearly match the inability of the
Protein_catabolism (development) of LTP associated with long-term potentiation
4) Confidence 0.06 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0 Pain Relevance 0.18

General Comments

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