INT197395

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Context Info
Confidence 0.19
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.81
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Serpinh1) endoplasmic reticulum (Serpinh1) protein maturation (Serpinh1)
response to stress (Serpinh1) cytoplasm (Serpinh1)
Anatomy Link Frequency
lens 3
cornea 1
Serpinh1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 8 71.60 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
Mechanotransduction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cataract 40 98.36 Very High Very High Very High
Wound Healing 25 94.12 High High
Fracture Healing 64 92.16 High High
Targeted Disruption 28 88.32 High High
Stress 30 79.60 Quite High
Osteoporosis 3 78.92 Quite High
Shock 30 75.40 Quite High
Injury 21 63.28 Quite High
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Corneal Opacity 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SERPINH1 was also found to be significantly overexpressed in the PF7 and PF10 ESTs.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of SERPINH1
1) Confidence 0.19 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.24 Pain Relevance 0
In light of these facts, the increased levels of Hsp 70 and Hsp 47 appeared to be major factors in the protection of the cornea and lens against lethal thermal damage, as well as played an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation.
Positive_regulation (increased) of Gene_expression (levels) of Hsp 47 in lens associated with wound healing and cataract
2) Confidence 0.15 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.29 Pain Relevance 0.04
In light of these facts, the increased levels of Hsp 70 and Hsp 47 appeared to be major factors in the protection of the cornea and lens against lethal thermal damage, as well as played an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation.
Positive_regulation (increased) of in cornea Gene_expression (levels) of Hsp 47 in lens associated with wound healing and cataract
3) Confidence 0.05 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.29 Pain Relevance 0.04

General Comments

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