INT197447

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.33
Pain Relevance 7.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (Psmd1) cellular_component (Psmd1)
Anatomy Link Frequency
body 2
Daoy 1
Psmd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 528 100.00 Very High Very High Very High
primary somatosensory cortex 366 100.00 Very High Very High Very High
Anterior cingulate cortex 402 99.80 Very High Very High Very High
Antinociceptive 54 98.62 Very High Very High Very High
narcan 36 98.36 Very High Very High Very High
c fibre 30 94.20 High High
analgesia 24 93.68 High High
agonist 36 93.60 High High
antagonist 36 92.64 High High
Analgesic 36 90.80 High High
Disease Link Frequency Relevance Heat
Body Weight 29 100.00 Very High Very High Very High
Targeted Disruption 589 99.68 Very High Very High Very High
Sprains And Strains 114 85.68 High High
Repression 1 81.84 Quite High
Convulsion 14 80.64 Quite High
Nociception 180 78.28 Quite High
Cancer 76 50.00 Quite Low
Infection 42 50.00 Quite Low
Hepatocellular Cancer 1 31.56 Quite Low
Tremor 2 30.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second landmark configuration consisted of 7 landmarks, 3 that reduced V1 to a triangle, 3 that reduced S1 to a triangle, and 1 that was the centroid of A1.
Negative_regulation (reduced) of S1 associated with primary somatosensory cortex
1) Confidence 0.33 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1578583 Disease Relevance 0.18 Pain Relevance 0.05
In the S1, morphine decreased the sink current evoked by electrical stimulation to 79.7 ± 13.0% of the control amplitude in WT mice (n = 9) and 47.7 ± 7.0% of the control amplitude in KO mice (n = 7).
Negative_regulation (decreased) of S1 associated with targeted disruption, primary somatosensory cortex and morphine
2) Confidence 0.32 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.56 Pain Relevance 1.01
The enhanced antinociceptive effect during behavioral tests was also observed as a result of the suppression of evoked synaptic currents in the S1 of the KO mice.
Negative_regulation (suppression) of S1 associated with targeted disruption, primary somatosensory cortex and antinociceptive
3) Confidence 0.32 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.49 Pain Relevance 1.73
In the S1, morphine decreased the CSD profile evoked by electrical stimulation to 61.5 ± 9.9% of the control amplitude in WT mice (n = 8) and 29.7 ± 6.7% of the control amplitude in KO mice (n = 6).
Negative_regulation (decreased) of S1 associated with targeted disruption, primary somatosensory cortex and morphine
4) Confidence 0.32 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.51 Pain Relevance 1.45
Morphine decreased the sink current in layer II/III in the S1 to 91.8 ± 4.0% of the control amplitude in WT mice (n = 8) and 63.1 ± 10% of the control amplitude in KO mice (n = 9).
Negative_regulation (decreased) of S1 associated with targeted disruption, primary somatosensory cortex and morphine
5) Confidence 0.32 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.41 Pain Relevance 1.01
The effect of morphine was reversed in both the S1 and ACC by intraperitoneal injection of naloxone (0.7 mg/kg).


Negative_regulation (reversed) of S1 associated with primary somatosensory cortex, narcan, anterior cingulate cortex and morphine
6) Confidence 0.32 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.47 Pain Relevance 1.60
Effects of morphine on laser evoked CSD profile and sink current components in the S1
Negative_regulation (evoked) of S1 associated with primary somatosensory cortex and morphine
7) Confidence 0.32 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.54 Pain Relevance 0.68
A Procrustes superimposition of 7 landmarks across V1, S1, and A1 from each of 16 adult C57BL/6J mice and 15 adult DBA/2J mice is shown in Figure 5.
Negative_regulation (superimposition) of S1 associated with primary somatosensory cortex
8) Confidence 0.28 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1578583 Disease Relevance 0.37 Pain Relevance 0.13
However, when females were analyzed separately they demonstrated a small but significant reduction in body weight (Text S1, Figure S1A and S1B).
Negative_regulation (reduction) of S1 in body associated with body weight
9) Confidence 0.18 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.37 Pain Relevance 0
These effects of miR-199b-5p on HES1 protein expression were not restricted to the stable clones or Daoy cells, as D283MED cells transiently transfected with the expression construct for miR-199b-5p also showed reduced HES1 levels (Text S1, Fig.
Negative_regulation (reduced) of S1 in Daoy
10) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.08 Pain Relevance 0
The average body weights of C3.Dll1tm1Gos/+ mice were also reduced at 6, 8, 10, and 12 weeks of age (Table S1).
Negative_regulation (reduced) of S1 in body associated with body weight
11) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.36 Pain Relevance 0
Oligos directly adjacent to each functional insert and in the opposite strand from the transcript hybridized intensely, with a rapid decrease in signal over a 200 base region (Figure S1).
Negative_regulation (decrease) of S1
12) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2698986 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox