INT197458

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 3.02
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sostdc1) extracellular region (Sostdc1)
Anatomy Link Frequency
nucleus accumbens 1
band 1
nociceptor 1
Sostdc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 439 100.00 Very High Very High Very High
Dopamine 103 100.00 Very High Very High Very High
Nucleus accumbens 47 100.00 Very High Very High Very High
Peripheral sensitization 22 100.00 Very High Very High Very High
withdrawal 214 99.22 Very High Very High Very High
nMDA receptor 134 98.88 Very High Very High Very High
qutenza 121 98.56 Very High Very High Very High
Inflammation 22 98.44 Very High Very High Very High
cocaine 33 98.12 Very High Very High Very High
Pain 176 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Paranoid Disorders 11 99.80 Very High Very High Very High
Anxiety Disorder 91 98.84 Very High Very High Very High
Shock 11 98.56 Very High Very High Very High
INFLAMMATION 22 98.44 Very High Very High Very High
Pain 231 98.04 Very High Very High Very High
Schizophrenia 22 97.60 Very High Very High Very High
Neuropathic Pain 55 91.60 High High
Hyperalgesia 88 91.04 High High
Depression 110 89.48 High High
Attention Deficit Hyperactivity Disorder 36 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consistent with previous data demonstrating that pretreatment with MK-801 blocks the development of sensitization to drugs of abuse including nicotine, cocaine, amphetamine or methamphetamine.94 Furthermore, these results also demonstrate that nicotine-induced behavioral sensitization requires the activation of NMDA receptors not only for its development, but also for its expression.
Positive_regulation (induced) of sensitization associated with nmda receptor, nicotine and cocaine
1) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615322 Disease Relevance 0.09 Pain Relevance 0.80
Therefore, blockade of NMDA receptors and NO formation can result in the development of nicotine-induced sensitization.
Positive_regulation (induced) of sensitization associated with nicotine and nmda receptor
2) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615322 Disease Relevance 0.07 Pain Relevance 0.89
In a series of experiments, Shoaib, Stolerman, and colleagues demonstrated that repeated co-administration of 0.3 mg/kg dizocilpine along with 0.4 mg/kg nicotine during several sensitization sessions attenuated sensitization to the locomotor stimulant effect of nicotine.87,88 This co-administration of dizocilpine also prevented sensitization of nicotine-induced dopamine release in the nucleus accumbens and the sensitized increase in nicotinic receptors in a variety of areas, including the nucleus accumbens,65 that normally occurs with repeated injections of nicotine.
Positive_regulation (increase) of sensitization in nucleus accumbens associated with nucleus accumbens, dopamine and nicotine
3) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615322 Disease Relevance 0 Pain Relevance 0.90
Peripheral sensitization is mediated by noxious input-dependent release of inflammatory neuromodulators which (by activating protein kinases) increase the transduction sensitivity and excitability of the nociceptor terminal.
Positive_regulation (mediated) of sensitization in nociceptor associated with inflammation, nociceptor and peripheral sensitization
4) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.61 Pain Relevance 0.75
In the snail Helix aspersa tentacle withdrawal reflex, for instance, mixed intrinsic-extrinsic sensitization may be induced by a strong intrinsic stimulus when combined with inputs from the CNS [27,49].
Positive_regulation (induced) of extrinsic sensitization associated with withdrawal
5) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.13 Pain Relevance 0.27
In some model systems habituation is induced by an innocuous stimulus (such as gentle touch) and sensitization is induced by noxious stimulus (forceful touch or electrical shock).
Positive_regulation (induced) of sensitization associated with shock
6) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.43 Pain Relevance 0.12
More commonly, sensitization is characterized as an increase in the response to a primary stimulus after priming by an extrinsic, often strong and noxious stimulus.
Positive_regulation (increase) of sensitization
7) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.25 Pain Relevance 0.31
According to the dual-process theory, sensitization may be induced by repeated applications of a primary, or intrinsic, stimulus.
Positive_regulation (induced) of sensitization
8) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.28 Pain Relevance 0.21
Rather than mediated by an extrinsic state system as originally proposed, sensitization induced by a repetitive primary stimulus could be expressed in the primary pathway(s) as with habituation, thus evidencing primary sensitization.
Positive_regulation (induced) of sensitization
9) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.33 Pain Relevance 0.33
This emphasis on expression instead of induction of sensitization circumvents the ambiguities in previous studies.
Positive_regulation (induction) of sensitization
10) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0 Pain Relevance 0.03
Further studies are needed to elucidate the possible role of associative learning in the induction of secondary sensitization and desensitization in these experimental models.


4.

Spec (possible) Positive_regulation (induction) of sensitization
11) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.08 Pain Relevance 0.03
In other systems habituation and sensitization could be induced by the same stimulus (e.g., startle response to repetitive loud noise).
Positive_regulation (induced) of sensitization associated with anxiety disorder
12) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.42 Pain Relevance 0.11
As pointed out by Prescott [31], it is important to distinguish the induction and expression phases of sensitization.
Positive_regulation (induction) of sensitization
13) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0 Pain Relevance 0.08
On the other hand, excessive band-selective filtering may lead to paranoia; indeed, increased sensitization and reduced habituation are trait markers of patients with schizophrenia [179].
Positive_regulation (increased) of sensitization in band associated with paranoid disorders and schizophrenia
14) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.33 Pain Relevance 0.03

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