INT197464

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.54
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Hbtq (Mus musculus)
Pain Link Frequency Relevance Heat
depression 30 92.48 High High
Neuropathic pain 1 83.68 Quite High
potassium channel 1 77.40 Quite High
Hippocampus 7 76.08 Quite High
addiction 66 61.04 Quite High
Pain 56 10.44 Low Low
withdrawal 50 5.00 Very Low Very Low Very Low
qutenza 33 5.00 Very Low Very Low Very Low
Morphine 25 5.00 Very Low Very Low Very Low
central sensitization 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 154 99.80 Very High Very High Very High
Shock 10 99.20 Very High Very High Very High
Anxiety Disorder 53 98.84 Very High Very High Very High
Sprains And Strains 197 98.40 Very High Very High Very High
Disease 26 92.88 High High
Depression 30 92.48 High High
Diabetes Mellitus-type I 7 87.68 High High
Genetic Predisposition To Disease 4 85.76 High High
Neuropathic Pain 16 83.68 Quite High
Ketoacidosis 1 66.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In other systems habituation and sensitization could be induced by the same stimulus (e.g., startle response to repetitive loud noise).
Positive_regulation (induced) of habituation associated with anxiety disorder
1) Confidence 0.01 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.43 Pain Relevance 0.11
In some model systems habituation is induced by an innocuous stimulus (such as gentle touch) and sensitization is induced by noxious stimulus (forceful touch or electrical shock).
Positive_regulation (induced) of habituation associated with shock
2) Confidence 0.01 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.43 Pain Relevance 0.12
Typically, habituation may be induced by a stimulus that is presented continuously or intermittently with a variable interstimulus interval (ISI).
Positive_regulation (induced) of habituation
3) Confidence 0.01 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.33 Pain Relevance 0.11
However, in the expanded RI set, the D2 allele is the allele with the higher effect and consequently results in a non-significant QTL (Fig. 3).


Positive_regulation (results) of QTL
4) Confidence 0.01 Published 2010 Journal Genes, Brain, and Behavior Section Body Doc Link PMC2855868 Disease Relevance 0.08 Pain Relevance 0.16
The database provides an overview of the extent of functional coding sequence variation between mouse inbred strains and will help to speed the identification of candidate genetic variations that underlie mouse QTL.


Positive_regulation (underlie) of QTL associated with sprains and strains
5) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1797019 Disease Relevance 0.31 Pain Relevance 0
The genomic location, primary protein sequence, and existence of non-synonymous mutations were used as evidence that mutations in Tas1r3 underlie this QTL.
Positive_regulation (underlie) of QTL
6) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1797019 Disease Relevance 0.47 Pain Relevance 0
A large number of QTL for type 1 diabetes have been identified in the NOD mouse model.
Positive_regulation (number) of QTL associated with diabetes mellitus
7) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.49 Pain Relevance 0

General Comments

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