INT197491

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 14.59
Pain Relevance 5.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Anatomy Link Frequency
brain 3
bone marrow 2
microglial cell 2
glial cells 2
macrophages 1
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 454 99.78 Very High Very High Very High
agonist 152 99.36 Very High Very High Very High
Inflammation 653 99.06 Very High Very High Very High
chemokine 120 99.04 Very High Very High Very High
Mechanotransduction 36 98.48 Very High Very High Very High
Bile 6 98.46 Very High Very High Very High
Inflammatory response 175 92.80 High High
Pyramidal cell 6 88.84 High High
COX-2 inhibitor 2 86.40 High High
addiction 3 85.60 High High
Disease Link Frequency Relevance Heat
Vasculitis 52 99.24 Very High Very High Very High
INFLAMMATION 727 99.06 Very High Very High Very High
Pneumonia 42 98.70 Very High Very High Very High
Diabetes Mellitus 39 98.44 Very High Very High Very High
Hypersensitivity 2 98.08 Very High Very High Very High
Systemic Lupus Erythematosus 122 97.88 Very High Very High Very High
Death 90 97.88 Very High Very High Very High
Disease 709 97.36 Very High Very High Very High
Fibrosis 26 97.00 Very High Very High Very High
Immunization 64 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of MyD88 by intrinsic vascular cells was necessary for cytokine and chemokine production and changes in vessel size, whereas MyD88 expression by bone marrow–derived cells was obligatory for changes in vessel size.
Gene_expression (Expression) of MyD88 in bone marrow associated with chemokine and cytokine
1) Confidence 0.74 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2605224 Disease Relevance 0.31 Pain Relevance 0.27
It is also possible that the MyD88-dependent effects we observe are not directly related to mechanotransduction signaling pathways, but rather to transcript instability in the absence of MyD88 expression, as described for IFN-?
Gene_expression (expression) of MyD88 associated with mechanotransduction
2) Confidence 0.74 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.50 Pain Relevance 0.22
Expression of MyD88 by intrinsic vascular cells was necessary for cytokine and chemokine production and changes in vessel size, whereas MyD88 expression by bone marrow–derived cells was obligatory for changes in vessel size.
Gene_expression (expression) of MyD88 in bone marrow associated with chemokine and cytokine
3) Confidence 0.74 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2605224 Disease Relevance 0.29 Pain Relevance 0.26
Our data do not contradict the recent finding that the absence of Myd88 leads to changes in the penetrance of diabetes in NOD mice raised in either SPF or gnotobiotic conditions.
Neg (absence) Gene_expression (absence) of Myd88 associated with diabetes mellitus
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666970 Disease Relevance 0.95 Pain Relevance 0
were observed at 10 days in the brain cortex of MPSIIIB mice, but not in MPSIIIB mice deleted for the expression of Toll-like receptor 4 or the adaptor protein MyD88, indicating early priming of microglial cells by heparan sulfate oligosaccharides in the MPSIIIB mouse brain.
Gene_expression (expression) of MyD88 in brain
5) Confidence 0.67 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2396504 Disease Relevance 0.84 Pain Relevance 0.21
However, suppression of microglial priming in MPSIIIB mice deleted for TLR4 and MyD88 showed dissociation between inflammation, which was absent or drastically reduced in young animals (10 days and 3 months), and expression of disease markers, which was unchanged.
Gene_expression (deleted) of MyD88 associated with inflammation and disease
6) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.98 Pain Relevance 0.20
In contrast to younger mice, inflammation in aged MPSIIIB mice was not affected by TLR4/MyD88 deficiency.


Gene_expression (deficiency) of MyD88 associated with inflammation
7) Confidence 0.58 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2396504 Disease Relevance 0.95 Pain Relevance 0.23
We compared the effect of mechanical ventilation on lung inflammation and permeability between poly(I:C) exposed mice with or without expression of MyD88.
Gene_expression (expression) of MyD88 in poly associated with inflammation and pneumonia
8) Confidence 0.58 Published 2010 Journal BMC Pulm Med Section Abstract Doc Link PMC3002319 Disease Relevance 0.55 Pain Relevance 0.36
Vascular cell and leukocyte expression of MyD88 are required for flow-mediated inward vascular remodeling
Gene_expression (expression) of MyD88 in leukocyte
9) Confidence 0.57 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.38 Pain Relevance 0.28
We used BM reconstitution experiments to characterize which cell types required MyD88 expression for flow-mediated vascular inflammation and inward remodeling.
Gene_expression (expression) of MyD88 associated with inflammation and vasculitis
10) Confidence 0.57 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.38 Pain Relevance 0.31
However, an alternative strategy takes advantage of the fact that all of the TLRs, with the exception of TLR3, as well as many of the early response cytokine receptors utilize the adapter protein, myeloid differentiation factor 88 (MyD88) [25,26].
Neg (exception) Gene_expression (utilize) of myeloid differentiation factor 88 associated with cytokine
11) Confidence 0.56 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.33 Pain Relevance 0.21
However, an alternative strategy takes advantage of the fact that all of the TLRs, with the exception of TLR3, as well as many of the early response cytokine receptors utilize the adapter protein, myeloid differentiation factor 88 (MyD88) [25,26].
Neg (exception) Gene_expression (utilize) of MyD88 associated with cytokine
12) Confidence 0.56 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.33 Pain Relevance 0.21
The contrasting phenotype of increased medial thickness and medial expansion after decreased blood flow in MyD88?
Gene_expression (expansion) of MyD88 in medial
13) Confidence 0.56 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.57 Pain Relevance 0.14
Absence of NaGlu, TLR4 or MyD88 expression was verified in brain extracts (table S1).
Gene_expression (expression) of MyD88 in brain
14) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0 Pain Relevance 0.03
With the aim to examine relationships between microglial cell priming by HS oligosaccharides and the progression of neuroinflammation and neurodegeneration in the brain with age, we studied MPSIIIB mice and produced MPSIIIB mice deficient for the expression of TLR4 or MyD88.
Gene_expression (expression) of MyD88 in brain
15) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0 Pain Relevance 0
agonist 15d-PGJ2 suppressed microglial expression of MyD88 and CD14
Gene_expression (expression) of MyD88 associated with agonist
16) Confidence 0.51 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.61 Pain Relevance 0.25
In some cases, MyD88 acts in concert with other adaptors, such as MAL/TIRAP, in the response triggered by stimulating TLR4, TLR1/2, and TLR2/6.
Gene_expression (acts) of MyD88
17) Confidence 0.51 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0 Pain Relevance 0
For example, it is rapidly becoming clear that a selective expression of the less-frequently used type of MyD88 in neurons, renders these cells uniquely sensitive to TLR-mediated activation of the JNK pathway to apoptosis, instead the NF-?
Gene_expression (expression) of MyD88 in neurons associated with apoptosis
18) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.18 Pain Relevance 0.27
This short form of MyD88 fails to recruit IRAK4, impairing the ability to phosphorylate IRAK1, therefore preventing the activation of NF?
Gene_expression (form) of MyD88
19) Confidence 0.48 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.13 Pain Relevance 0.16
Two independent groups have shown that inhibiting MyD88 impairs the phosphorylation/activation of downstream kinases [86] and NF?
Neg (impairs) Gene_expression (impairs) of MyD88
20) Confidence 0.48 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.58 Pain Relevance 0.07

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