INT197492

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.95
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 99.40 Very High Very High Very High
Pyramidal cell 6 89.36 High High
chemokine 3 73.56 Quite High
Intracerebroventricular 16 27.20 Quite Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 31 99.40 Very High Very High Very High
Neurodegenerative Disease 9 93.64 High High
Death 4 92.48 High High
Disease 46 90.04 High High
Encephalitis 7 86.44 High High
Disorder Of Lipid Metabolism 4 85.92 High High
Mucopolysaccharidoses 3 75.00 Quite High
Cv General 2 Under Development 1 69.08 Quite High
Motor Neuron Diseases 6 59.92 Quite High
Brain Injury 3 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to younger mice, inflammation in aged MPSIIIB mice was not affected by TLR4/MyD88 deficiency.


Neg (not) Regulation (affected) of Gene_expression (deficiency) of MyD88 associated with inflammation
1) Confidence 0.39 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2396504 Disease Relevance 1.00 Pain Relevance 0.23
Furthermore, we have shown that reversible spino-dendritic degeneration in this LPS model is dependent on expression of CD14, TLR4 (but not TLR2), MyD88, the p50 subunit of NF-?
Regulation (dependent) of Gene_expression (expression) of MyD88
2) Confidence 0.17 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.94 Pain Relevance 0.04

General Comments

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